ArticleOpen forum infectious diseases2021
Lymphopenia Is Associated With Poor Outcomes of Patients With Community-Acquired Pneumonia and Sepsis.
Article in Open forum infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 63 citations in OpenAlex.
- Risk factors and predicting nomogram for the clinical deterioration of non-severe community-acquired pneumonia.BMC pulmonary medicine · 2024Trial
- First-week absolute lymphocyte count dynamics and 28-day mortality in older adults with sepsis.BMC infectious diseases · 2026Article
- Relationship between systemic immune-inflammation index and risk of mortality among pneumonia patients: a systematic review with meta-analysis.Journal of thoracic disease · 2026Article
- Lymphopenia in Bacterial Sepsis and SARS-CoV-2 Infection.Biomedicines · 2026Article
- Immune dysregulation through longitudinal lymphocyte trajectories and their clinical determinants in hospitalized COVID-19 patients.Intensive care medicine experimental · 2026Article
- Corticosteroids in severe community-acquired pneumonia: friend, foe or both?Pneumonia (Nathan Qld.) · 2026Review
- The incremental value of a novel immuno-inflammatory index (SIICI) in predicting sepsis after ureteroscopic lithotripsy: development and validation of a nomogram.Frontiers in cellular and infection microbiology · 2026Article
- Development and validation of machine learning-based prediction for in-hospital mortality in ICU patients with severe community-acquired pneumonia and respiratory failure.Frontiers in medicine · 2026Article
- Early lymphocyte recovery predicts cardiovascular events and mortality in immune checkpoint inhibitor-associated myocarditis: a retrospective cohort study.Frontiers in cardiovascular medicine · 2026Article
- PLA2G2A is a candidate biomarker for sepsis diagnosis in mice through machine learning algorithms.Frontiers in immunology · 2026Article
- Impact of baseline lymphopenia on prognosis of patients with septic shock.BMC infectious diseases · 2025Article
- A Large-Scale Single-Cell Atlas Reveals the Peripheral Immune Panorama of Bacterial Pneumonia.American journal of respiratory and critical care medicine · 2025Article
- Higher soluble CD8 correlates with poor prognosis in hospitalized pulmonary infection patients.Annals of medicine · 2025Article
- Association between prognostic nutritional index and 90-day mortality in septic patients: a retrospective cohort study.BMC nutrition · 2025Article
- Time series modeling shows early lymphocyte decline predicts inflammatory rise and mortality in older adults with community acquired pneumonia.Scientific reports · 2025Article
- Acute Respiratory Distress Syndrome in Patients with Lymphopenia: Results from the National Inpatient Sample (2017-2021).Journal of clinical medicine · 2025Article
- Machine Learning Reveals the Value of Unconventional T Lymphocytes in Sepsis and Prognosis of Elderly Patients With Severe Lower Respiratory Tract Infections.Journal of clinical laboratory analysis · 2025Article
- Why should lymphocytes immune profile matter in sepsis?World journal of critical care medicine · 2025Review
- The Prognostic Value of the CALLY Index in Sepsis: A Composite Biomarker Reflecting Inflammation, Nutrition, and Immunity.Diagnostics (Basel, Switzerland) · 2025Article
- Risk factors for prolonged infection and secondary infection in pediatric severe sepsis.Infection · 2025Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLymphopenia is a marker of poor prognosis in patients with community-acquired pneumonia (CAP), yet its impact on outcomes in patients with CAP and sepsis remains unknown. We aim to investigate the impact of lymphopenia on outcomes, risk of intensive care unit (ICU) admission, and mortality in CAP patients with sepsis.
methodsThis was a retrospective, observational study of prospectively collected data from an 800-bed tertiary teaching hospital (2005-2019).
resultsOf the 2203 patients with CAP and sepsis, 1347 (61%) did not have lymphopenia, while 856 (39%) did. When compared with the nonlymphopenic group, patients with sepsis and lymphopenia more frequently required ICU admission (
conclusionsLymphopenia was independently associated with risk of ICU admission and higher in-hospital and 30-day mortality in patients with CAP and sepsis. Early identification of lymphopenia could help identify septic patients with CAP who require or will shortly require critical care.
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