ArticleJournal of biomedical physics & engineering2021
Hesperidin Modulates Troponin-1 Serum Level and Decrease Heart Tissue Injury of Irradiated Rats.
Article in Journal of biomedical physics & engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe heart is the major dose-limiting organ for radiotherapy of malignant tumor in the mediastanal region.
objectiveThis study aims to investigate the radio protective effects of Hesperidin (HES) as a natural flavonoid after localized irradiation of the rat's mediastinum region. MATERIAL AND
methodsIn this experimental study, we divided sixty male rats into 4 groups (n=15). First group: Sham which received PBS; second group: Hesperidin only (100 mg/kg/day orally) for one week; third group: Radiation that received single dose of 20 Gy gamma radiation using Co-60 unit and the forth group: Radiation+HES that underwent the same dose of radiation and received HES for 7 days prior irradiation. Each group was divided in two branches. Early sampling from subgroup one was done 4-6 hours after irradiation to determine troponin-1 level changes. Rats of second subgroups were killed 56 days after irradiation for histopathological evidence.
resultsIn radiation group, troponin -1 serum level had a significant increase in comparison with sham group (P<0.05). Histopathological evaluation of second subgroup showed there was a significant difference between sham and radiation group in some parameters. Inflammation (p=0.008), pericardial effusion (P=0.001), and vascular plaque (P=0.001) had an increase in the irradiation group. Oral administration of hesperidin significantly decreased all the above factors when was compared with irradiation group (P>0.016).
conclusionOral administration of Hesperidine for seven days prior radiotherapy may decrease troponin-1 and cardiac injury due to radiation.
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