Evidence map›Paper›PMID 34189071›Full record

ArticleWorld journal of clinical oncology2021

Phytochemically rich dietary components and the risk of colorectal cancer: A systematic review and meta-analysis of observational studies.

Pia Borgas, Guadalupe Gonzalez, Kirill Veselkov, Reza Mirnezami

Open access · diamondAbstract read
In one paragraph

Article in World journal of clinical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Associations Between Prescreening Dietary Patterns and Longitudinal Colonoscopy Outcomes in Veterans.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Pia BorgasFaculty of Medical Sciences, University College London, London WC1E 6BT, United Kingdom.
Guadalupe GonzalezDepartment of Computing, Imperial College London, London SW7 2RH, United Kingdom.
Kirill VeselkovDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom.
Reza MirnezamiDepartment of Colorectal Surgery, Royal Free Hospital, London NW3 2QG, United Kingdom. reza.mirnezami@nhs.net.
Imperial College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPersonalized nutrition and protective diets and lifestyles represent a key cancer research priority. The association between consumption of specific dietary components and colorectal cancer (CRC) incidence has been evaluated by a number of population-based studies, which have identified certain food items as having protective potential, though the findings have been inconsistent. Herein we present a systematic review and meta-analysis on the potential protective role of five common phytochemically rich dietary components (nuts, cruciferous vegetables, citrus fruits, garlic and tomatoes) in reducing CRC risk.

aimTo investigate the independent impact of increased intake of specific dietary constituents on CRC risk in the general population.

methodsMedline and Embase were systematically searched, from time of database inception to January 31, 2020, for observational studies reporting CRC incidence relative to intake of one or more of nuts, cruciferous vegetables, citrus fruits, garlic and/or tomatoes in the general population. Data were extracted by two independent reviewers and analyzed in accordance with the Meta-analysis of Observational Studies in Epidemiology (MOOSE) and Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) reporting guidelines and according to predefined inclusion/exclusion criteria. Effect sizes of studies were pooled using a random-effects model.

resultsForty-six studies were identified. CRC risk was significantly reduced in patients with higher

conclusionIncreased cruciferous vegetable, garlic, citrus fruit and tomato consumption are all inversely associated with CRC risk. These findings highlight the potential for developing precision nutrition strategies for CRC prevention.

Indexed as

Colorectal cancerDietDisease preventionMeta-analysisNutrigenomicsRisk

Identifiers

PMID34189071
PMCPMC8223713
OpenAlexW3176030812

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.