Evidence map›Paper›PMID 34189064›Full record

ArticleBiotechnology reports (Amsterdam, Netherlands)2021

Global transcriptome profiling reveals genes responding to overproduction of a small secretory, a high cysteine- and a high glycosylation-bearing protein in

Paulina Korpys-Woźniak, Ewelina Celińska

Abstract read
In one paragraph

Article in Biotechnology reports (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
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  7. Review
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  14. Employing Engineered Enolase Promoter for Efficient Expression ofInternational journal of molecular sciences · 2022
    Article
  15. Article
  16. Review
  17. Synthesis of Secretory Proteins inInternational journal of molecular sciences · 2022
    Article
  18. Article
  19. Secretory helpers for enhanced production of heterologous proteins inBiotechnology reports (Amsterdam, Netherlands) · 2021
    Article
  20. Epigenetic Response ofMicroorganisms · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Paulina Korpys-WoźniakDepartment of Biotechnology and Food Microbiology, Poznan University of Life Sciences, ul. Wojska Polskiego 48, 60-637, Poznań, Poland.
Ewelina CelińskaDepartment of Biotechnology and Food Microbiology, Poznan University of Life Sciences, ul. Wojska Polskiego 48, 60-637, Poznań, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Investigation of the yeast cell's response to recombinant secretory protein (rs-Prot) overproduction is relevant for both basic and applied research. Imbalance, overloading or stress within this process impacts the whole cell. In the present study, by using steady-state cultures and transcriptomics, we investigated the cellular response of

Indexed as

DEG(s), differentially expressed gene(s)ER, endoplasmic reticulumHeterologous proteinsHSS(s), high-secretor strain(s)Metabolic burdenPichia pastoris, traditional name for the renamed Komagataella phaffiir(s)-Prot, recombinant (secretory) heterologous proteinSecretory pathwaySOA/TLG/SCYFP/INYFP, genes encoding the target heterologous proteins (capitalized and italicized)SoA/TlG/scYFP/inYFP, heterologous proteins (small and non-italicized)SoA/TlG/scYFP/inYFP, strains overproducing a given heterologous protein (small and italicized letters)TranscriptomicsUPR, unfolded protein response. Genes names are given as shortened codes without preceding YALI0_Yeast

Identifiers

PMID34189064
PMCPMC8220174

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.