Evidence map›Paper›PMID 34188756›Full record

ArticleIEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium2020

Dose-dependent effects of ultrasound therapy on hepatocellular carcinoma.

Laith R Sultan, Julia C D'Souza, Mrigendra B Karmacharya, Stephen J Hunt, Angela K Brice, Terence Gade, Andrew Kw Wood, Chandra M Sehgal

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Laith R SultanDepartment of Radiology, University of Pennsyvlania, Philadelphia, PA, USA.
Julia C D'SouzaDepartment of Radiology, University of Pennsyvlania, Philadelphia, PA, USA.
Mrigendra B KarmacharyaDepartment of Radiology, University of Pennsyvlania, Philadelphia, PA, USA.
Stephen J HuntDepartment of Radiology, University of Pennsyvlania, Philadelphia, PA, USA.
Angela K BriceDepartment of Radiology, University of Pennsyvlania, Philadelphia, PA, USA.
Terence GadeDepartment of Radiology, University of Pennsyvlania, Philadelphia, PA, USA.
Andrew Kw WoodDepartment of Radiology, University of Pennsyvlania, Philadelphia, PA, USA.
Chandra M SehgalDepartment of Radiology, University of Pennsyvlania, Philadelphia, PA, USA.
Penn Center for AIDS Research · USUniversity of Pennsylvania · US

Funding

Antivascular ultrasound therapy of primary liver neoplasiaR01CA204446 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SEHGAL, CHANDRA M · 2017 to 2021
$2.0M
Tunable microbubbles for antivascular ultrasoundR01EB022612 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI SEHGAL, CHANDRA M · 2016 to 2019
$1.6M
Integrated photoacoustic and ultrasound imaging with the Vevo LAZRS10OD016310 · OD · UNIVERSITY OF PENNSYLVANIA · PI SEHGAL, CHANDRA M · 2014 to 2014
$494k
NCI NIH HHS R01 CA204446NIBIB NIH HHS R01 EB022612NIH HHS S10 OD016310
6 · The paper itself

Abstract

Non-invasive ischemic cancer therapy requires reduced blood flow whereas drug delivery and radiation therapy require increased tumor perfusion for a better response. In this study we investigate the hypothesis that different dose models of antivascular ultrasound therapy (AVUS) can have opposite effects on hepatocellular carcinoma (HCC) tumor blood flow. HCC was induced in 22 Wistar rats by ingestion of diethylnitrosamine (DEN) for 12 weeks. Rats received AVUS treatment at low and high doses. Low dose group received 1 watt/cm

Indexed as

cancer therapycontrast enhanced ultrasoundhepatocellular carcinomaquantitative imagingtherapeutic ultrasound

Identifiers

PMID34188756
PMCPMC8237379
OpenAlexW3102123998

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.