ArticleThe Journal of clinical and aesthetic dermatology2021
Guideline for the Management of Hyaluronic Acid Filler-induced Vascular Occlusion.
Article in The Journal of clinical and aesthetic dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Guide for Managing Vascular Occlusion Caused by Fillers with Exclusive Cutaneous Involvement: A Review of Diagnosis, Classification, and Treatment.Aesthetic plastic surgery · 2026Pooled it
- Hyaluronidase Protocol in Management of Hyaluronic Acid Filler-Related Vascular Complications: A Systematic Review and Meta-Analysis.Aesthetic plastic surgery · 2026Pooled it
- Arterial Embolism After Facial Fat Grafting: A Systematic Literature Review.Aesthetic plastic surgery · 2023Pooled it
- Increasing Facial Attractiveness by Lateralizing the Auricle-Analyzing the Pan-Facial Effects of the Postauricular Injection Technique in Chinese Patient Populations.Aesthetic plastic surgery · 2025Trial
- Beyond reconstruction: minimally invasive aesthetic and regenerative medicine in postoperative oral and maxillofacial surgery.Oral and maxillofacial surgery · 2026Review
- Efficacy and Safety of Hyaluronic Acid Injection for Labia Majora Atrophy in the Chinese Population.Aesthetic plastic surgery · 2026Article
- Managing residual volumes in penile girth enhancement with hyaluronic acid fillers: a case series and literature review.International journal of impotence research · 2026Review
- Retiform purpura as the clinical indicator of vascular occlusion after intra-articular knee viscosupplementation.JAAD case reports · 2026Article
- Ultrasound Imaging of High-Risk Facial Areas for Injectables: A Practical Guide for Common Scenarios.Aesthetic plastic surgery · 2026Review
- Ultrasound-Guided Low-Dose Hyaluronidase for Infraorbital Artery Occlusion with Secondary Gingival Ischemia After Hyaluronic Acid Filler Injection: A Case Report.Diagnostics (Basel, Switzerland) · 2026Article
- Doppler Ultrasound Findings in Filler-Related Facial Vascular Adverse Events: An International Multicenter Study.Diagnostics (Basel, Switzerland) · 2026Article
- Hyperbaric Oxygen Therapy in the Management of Dermal Filler-Induced Vascular Occlusion: A Scoping Review.The Journal of clinical and aesthetic dermatology · 2026Review
- Hyaluronic Acid Dermal Filler-Associated Vascular Occlusion-A Review of Prevention and Management Strategies.Journal of cosmetic dermatology · 2026Review
- Atypical Hyaluronic Acid-Induced Vascular Occlusion Masked by a Hematoma: Ultrasound-Guided Diagnosis and Management.Cureus · 2026Article
- Advanced Regenerative Drainage and Immunomodulatory Protocol for Dermal Filler-Induced Skin Necrosis: A Prospective Clinical Case Series.Journal of cosmetic dermatology · 2026Article
- Superselective Internal Pudendal Artery Thrombolytic Therapy Combined With Concentrated Growth Factor for Hyaluronic Acid Embolization After Vulvovaginal Rejuvenation: A Case Report and Review of Literature.Aesthetic plastic surgery · 2026Review
- Article
- Agarose Gel as an Injectable Filler Significantly Reduced the Risk of Rabbit Retinal Artery Embolism Compared to Hyaluronic Acid.Aesthetic plastic surgery · 2026Article
- [Soft tissue fillers : Anatomical principles, mechanisms of action, and safe utilization in aesthetic medicine].Dermatologie (Heidelberg, Germany) · 2026Review
- A Hybrid Gel of Hyaluronic Acid and Poly-L-Lactic Acid for Nasolabial Folds by Ligament-targeted Injection.Plastic and reconstructive surgery. Global open · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vascular occlusions can occur with injection of dermal fillers causing devastating outcomes for the patient. The occurrence, and subsequent management, of these negative outcomes is a source of significant stress to the aesthetic clinician. Complications management is an essential component of clinical practice and professionals must develop competence and confidence in the identification and effective treatment of a vascular occlusion. The relatively rare occurrence of a vascular occlusion mandates that learning must be largely through the study of theory in addition to the sharing of learning experiences within a collaborative clinical community. The delivery of optimal care begins with an understanding of the underlying pathophysiology and the ability to assess and elicit clinical signs. Establishing a clinical diagnosis, targeted therapy can commence in a timely fashion. This paper provides guidance on how to identify and manage a vascular occlusion caused by cross-linked hyaluronic acid. It provides a detailed description of the pathological process of tissue ischemia, and introduces identifiable stages which will help to determine the extent of ischemia and the time frame since ischemic onset. The stages are particularly important as they highlight when wound support may be needed.
Indexed as
Identifiers
34188752PMC8211329W3174029792What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.