Evidence map›Paper›PMID 34188450›Full record

SynthesisDrug design, development and therapy2021

Chemistry, Pharmacology and Therapeutic Potential of Swertiamarin - A Promising Natural Lead for New Drug Discovery and Development.

Nur Sakinah Muhamad Fadzil, Mahendran Sekar, Siew Hua Gan, Srinivasa Reddy Bonam, Yuan Seng Wu, Jaishree Vaijanathappa, Subban Ravi, Pei Teng Lum, Shivsharan B Dhadde

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Drug design, development and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Antioxidants (Basel, Switzerland) · 2025
    Article
  8. Review
  9. Review
  10. The protective effect ofFrontiers in nutrition · 2025
    Article
  11. Article
  12. Review
  13. Molecular Actions ofAnti-cancer agents in medicinal chemistry · 2024
    Article
  14. Article
  15. Article
  16. Chromatographic analysis of selected phytosterols fromCurrent research in toxicology · 2023
    Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Nur Sakinah Muhamad FadzilDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, Perak, Malaysia.
Mahendran SekarDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, Perak, Malaysia.ORCID 0000-0002-3022-6137
Siew Hua GanSchool of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia.ORCID 0000-0001-6470-3651
Srinivasa Reddy BonamInstitut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Equipe-Immunopathologie et Immunointervention Thérapeutique, Sorbonne Université, Université de Paris, Paris, France.ORCID 0000-0002-2888-2418
Yuan Seng WuDepartment of Biochemistry, School of Medicine, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Bandar Saujana Putra, Selangor, Malaysia.
Jaishree VaijanathappaDepartment of Pharmaceutical Chemistry, JSS College of Pharmacy, Mysuru, Karnataka, India.
Subban RaviDepartment of Chemistry, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, India.
Pei Teng LumDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, Perak, Malaysia.
Shivsharan B DhaddeD.S.T.S. Mandal's College of Pharmacy, Solapur, Maharashtra, India.
University of Kuala Lumpur · MYInserm · FRJSS Academy of Higher Education and Research · INKarpagam Academy of Higher Education · INMahsa University · MYMonash University Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Swertiamarin, a seco-iridoid glycoside, is mainly found in

Indexed as

Drug DevelopmentAnimalsDrug DiscoveryGentianaceaeHumansIridoid GlucosidesPlant ExtractsPyronesIridoid GlucosidesPlant ExtractsPyronesswertiamarinbiosynthesisEnicostemma littoraleinflammatory cytokinesmetabolic pathwaymolecular targetsswertiamarin

Identifiers

PMID34188450
PMCPMC8233004
OpenAlexW3177382940

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.