Evidence map›Paper›PMID 34188208›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2021

Effect of the traditional Chinese medicine Pinggan-Qianyang decoction on SIRT1-PTEN signaling in vascular aging in spontaneously hypertensive rats.

Zhang Cui, Yao Jiamei, Yang Yushu, Fang Xia, Yang Haiyan, Dan Zhang, Chen Qiong, Zhong Guangwei

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Cellular and molecular mechanisms underlying cardiovascular aging.Cellular & molecular biology letters · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Zhang Cui *International Medical Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P.R. China.
Yao Jiamei *International Medical Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P.R. China.
Yang YushuInternational Medical Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P.R. China.
Fang XiaInternational Medical Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P.R. China.
Yang HaiyanInternational Medical Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P.R. China.
Dan ZhangInternational Medical Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P.R. China.
Chen QiongInternational Medical Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P.R. China.
Zhong GuangweiInternational Medical Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P.R. China. zgw7512@sina.com.
Central South University · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related functional decline is a physiological phenomenon that occurs in all organ systems. However, the acceleration and early occurrence of this process are observed in cardiovascular pathologies, including hypertension. This study aimed to investigate SIRT1-PTEN signaling in aortic tissue from spontaneously hypertensive rats (SHRs) and changes in SIRT1 and PTEN expression following treatment with Pinggan-Qianyang decoction (PGQYD) and explore the mechanism involved in the treatment of hypertensive vascular aging with traditional Chinese medicine. In this study, we used two rat models: spontaneously hypertensive rats (SHRs) at 14 and 64 weeks of age and WKY rats at 64 weeks of age. The degree of irritability and rotation tolerance time were evaluated to determine the effects of PGQYD on animal behavior. The morphology of the thoracic aorta was examined by hematoxylin-eosin (HE) and Masson staining and electron microscopy. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and superoxide dismutase (SOD) and anti-superoxide anion content were detected. Senescence-associated β-galactosidase (SA-β-Gal) staining was used to observe the thoracic aorta during vascular aging. RT-qPCR, immunofluorescence, and Western blot analysis were performed to detect changes in the mRNA and protein expression of p53, p21, SIRT1, and PTEN in rat aortic tissues. Behavioral tests and histological and morphological analyses showed the remarkable amelioration of vascular aging after PGQYD treatment compared with that in the older SHRs. Moreover, PGQYD significantly decreased vascular aging in SHRs, as indicated by reduced SA-β-Gal staining, NADPH oxidase activity, and p53 and p21 expression, and increased anti-superoxide anion and SOD content. Furthermore, PGQYD increased SIRT1 and PTEN expression, but the downregulated expression of SIRT1 induced by a SIRT1 inhibitor abolished the PGQYD-induced antiaging effects on gene expression and antioxidant activity and enhanced PTEN expression. PGQYD could ameliorate vascular aging effects in SHRs, which may have been mediated via the regulation of SIRT1-PTEN signaling in aortic tissue.

Indexed as

HypertensionSirtuin 1AgingAnimalsMedicine, Chinese TraditionalPTEN PhosphohydrolaseRatsRats, Inbred SHRRats, Inbred WKYPTEN PhosphohydrolasePten protein, ratSirt1 protein, ratSirtuin 1Phosphatase and tensin homology deleted on chromosome ten (PTEN)Pinggan-Qianyang decoctionSilent information regulator 1 (SIRT1)Spontaneously Hypertensive RatVascular aging

Identifiers

PMID34188208
PMCPMC8418988
OpenAlexW3174141560

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.