ArticleThe ISME journal2021
Decline in symbiont-dependent host detoxification metabolism contributes to increased insecticide susceptibility of insects under high temperature.
Article in The ISME journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.
- Impact of heat stress on the fitness outcomes of symbiotic infection in aphids: a meta-analysis.Proceedings. Biological sciences · 2022Pooled it
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- Diversity of culturable gut bacteria associated with brown planthopper, Nilaparvata lugens (Stål) and their role in imidacloprid degradation.Scientific reports · 2026Article
- The Effect of Ammonia on the Host-Parasite SystemBiology · 2026Article
- Gut Microbe-Driven Resistance Mechanisms in Propylea Japonica: Insights from Horizontal Gene Transfer and Oxidative Phosphorylation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Diversity of Bacterial Symbionts in Major Agricultural Lepidopteran Pests in Australia.International journal of microbiology · 2026Article
- Predicting the Potential Distribution ofBiology · 2025Article
- Assessing gut microbiota diversity and functional potential in resistant and susceptible strains of the mediterranean fruit fly.Scientific reports · 2025Article
- Mechanisms and Genetic Drivers of Resistance of Insect Pests to Insecticides and Approaches to Its Control.Toxics · 2025Review
- Assessing the Potential Distribution ofEcology and evolution · 2025Article
- Bacterial communities inHeliyon · 2025Article
- Article
- Cooperative microbial metabolism enhances tryptophan-mediated insecticide detoxification in the fall armyworm.The ISME journal · 2025Article
- Symbiotic bacteria associated with different species ofFrontiers in microbiology · 2025Article
- Symbiont community assembly shaped by insecticide exposure and feedback on insecticide resistance of Spodoptera frugiperda.Communications biology · 2024Article
- Article
- Microbial Symbiont-Based Detoxification of Different Phytotoxins and Synthetic Toxic Chemicals in Insect Pests and Pollinators.Journal of xenobiotics · 2024Review
- Managing Super Pests: Interplay between Pathogens and Symbionts Informs Biocontrol of Whiteflies.Microorganisms · 2024Article
- Insecticide susceptibility in a planthopper pest increases following inoculation with cultured Arsenophonus.The ISME journal · 2024Article
- The influence of high-temperature frequency variation on the life-history traits of pyridaben-sensitive and -resistant strains of Tetranychus truncatus.Experimental & applied acarology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interactions between insects and their bacterial symbionts are shaped by a variety of abiotic factors, including temperature. As global temperatures continue to break high records, a great deal of uncertainty surrounds how agriculturally important insect pests and their symbionts may be affected by elevated temperatures, and its implications for future pest management. In this study, we examine the role of bacterial symbionts in the brown planthopper Nilaparvata lugens response to insecticide (imidacloprid) under different temperature scenarios. Our results reveal that the bacterial symbionts orchestrate host detoxification metabolism via the CncC pathway to promote host insecticide resistance, whereby the symbiont-inducible CncC pathway acts as a signaling conduit between exogenous abiotic stimuli and host metabolism. However, this insect-bacterial partnership function is vulnerable to high temperature, which causes a significant decline in host-bacterial content. In particular, we have identified the temperature-sensitive Wolbachia as a candidate player in N. lugens detoxification metabolism. Wolbachia-dependent insecticide resistance was confirmed through a series of insecticide assays and experiments comparing Wolbachia-free and Wolbachia-infected N. lugens and also Drosophila melanogaster. Together, our research reveals elevated temperatures negatively impact insect-bacterial symbiosis, triggering adverse consequences on host response to insecticide (imidacloprid) and potentially other xenobiotics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.