ArticleJournal of exposure science & environmental epidemiology2022
Estimating mouthing exposure to chemicals in children's products.
Article in Journal of exposure science & environmental epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Migration of phthalates and per- and polyfluoroalkyl substances from paper and plastic drinking straws immersed in human saliva: a pilot migration study.Annals of occupational and environmental medicine · 2026Article
- Stuffed toys as a source of oral PFAS exposure: Migration into artificial saliva and exposure assessment.Journal of exposure science & environmental epidemiology · 2026Article
- Application of a computer vision algorithm to quantify the frequency and duration of children's microactivities in different play scenarios.Journal of exposure science & environmental epidemiology · 2026Article
- A transdisciplinary process-oriented approach to evaluate infant exposure to indoor dust.Journal of exposure science & environmental epidemiology · 2026Article
- USEtox modeling of children's exposures to Bisphenol A (BPA) and alternatives in toys.Journal of exposure science & environmental epidemiology · 2026Article
- Parental reporting of activities relevant for young children's soil/dust ingestion.Scientific reports · 2026Article
- Analysis of durations and frequencies of mouthing behaviors in children 6 months to 6 years: an advanced videotaping and translation approach.Frontiers in public health · 2026Article
- Additive inclusion in plastic life cycle assessments, part II: Review of additive inventory data trends and availability.Journal of industrial ecology · 2024Article
- Probabilistic Reference and 10% Effect Concentrations for Characterizing Inhalation Non-cancer and Developmental/Reproductive Effects for 2,160 Substances.Environmental science & technology · 2024Article
- An assessment of the ECETOC TRA Consumer tool performance as a screening level tool.Journal of exposure science & environmental epidemiology · 2023Article
- Probabilistic Points of Departure and Reference Doses for Characterizing Human Noncancer and Developmental/Reproductive Effects for 10,145 Chemicals.Environmental health perspectives · 2023Article
- Simplified Unified BARGE Method to Assess Migration of Phthalate Esters in Ingested PVC Consumer Products.International journal of environmental research and public health · 2023Article
- Advances in computational methods along the exposure to toxicological response paradigm.Toxicology and applied pharmacology · 2022Article
- Exposure modelling in Europe: how to pave the road for the future as part of the European Exposure Science Strategy 2020-2030.Journal of exposure science & environmental epidemiology · 2022Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExisting models for estimating children's exposure to chemicals through mouthing currently depends on the availability of chemical- and material-specific experimental migration rates, only covering a few dozen chemicals.
objectiveThis study objective is hence to develop a mouthing exposure model to predict migration into saliva, mouthing exposure, and related health risk from a wide range of chemical-material combinations in children's products.
methodsWe collected experimental data on chemical migration from different products into saliva for multiple substance groups and materials, identifying chemical concentration and diffusion coefficient as main properties of influence. To predict migration rates into saliva, we adapted a previously developed migration model for chemicals in food packaging materials. We also developed a regression model based on identified chemical and material properties.
resultsOur migration predictions correlate well with experimental data (R SIGNIFICANCE: The proposed model can be applied for predicting migration rates for hundreds of chemical-material combinations to support high-throughput screening.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.