ArticleScientific reports2021
The impact of myocardial compressibility on organ-level simulations of the normal and infarcted heart.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Physics-Informed Reconstruction of Transmural Myocardial Deformation from 3D Echocardiography: Validation Against Cardiac MRI.Annals of biomedical engineering · 2026Article
- Computational modeling of left ventricular flow using PC-CMR-derived four-dimensional wall motion.International journal of engineering science · 2026Article
- Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling.Advanced healthcare materials · 2026Review
- Minimally invasive delivery of engineered heart tissues restores cardiac function in rats with chronic myocardial infarction.Acta biomaterialia · 2026Article
- Adamts1 Exacerbates Post-Myocardial Infarction Scar Formation via Mechanosensing of Integrin α8.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Complete spatiotemporal quantification of cardiac motion in mice through multi-view magnetic resonance imaging and super-resolution reconstruction.Scientific reports · 2025Article
- Deep Learning-Based Estimation of Myocardial Material Parameters from Cardiac MRI.Bioengineering (Basel, Switzerland) · 2025Article
- A Neural Network Finite Element Trileaflet Heart Valve Model Incorporating Multi-Body Contact.International journal for numerical methods in biomedical engineering · 2025Article
- In-silico heart model phantom to validate cardiac strain imaging.Computers in biology and medicine · 2024Article
- Simulated Effects of Acute Left Ventricular Myocardial Infarction on Mitral Regurgitation in an Ovine Model.Journal of biomechanical engineering · 2024Article
- In-silico heart model phantom to validate cardiac strain imaging.bioRxiv : the preprint server for biology · 2024Article
- Whole-heart electromechanical simulations using Latent Neural Ordinary Differential Equations.NPJ digital medicine · 2024Article
- A biomechanics-based parametrized cardiac end-diastolic pressure-volume relationship for accurate patient-specific calibration and estimation.Scientific reports · 2023Article
- A multi-scale computational model for the passive mechanical behavior of right ventricular myocardium.Journal of the mechanical behavior of biomedical materials · 2023Article
- Contractile Adaptation of the Left Ventricle Post-myocardial Infarction: Predictions by Rodent-Specific Computational Modeling.Annals of biomedical engineering · 2023Article
- Neural Network Approaches for Soft Biological Tissue and Organ Simulations.Journal of biomechanical engineering · 2022Review
- Simulation of the 3D Hyperelastic Behavior of Ventricular Myocardium using a Finite-Element Based Neural-Network Approach.Computer methods in applied mechanics and engineering · 2022Article
- Patient-Specific Inverse Modeling of In Vivo Cardiovascular Mechanics with Medical Image-Derived Kinematics as Input Data: Concepts, Methods, and Applications.Applied sciences (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Myocardial infarction (MI) rapidly impairs cardiac contractile function and instigates maladaptive remodeling leading to heart failure. Patient-specific models are a maturing technology for developing and determining therapeutic modalities for MI that require accurate descriptions of myocardial mechanics. While substantial tissue volume reductions of 15-20% during systole have been reported, myocardium is commonly modeled as incompressible. We developed a myocardial model to simulate experimentally-observed systolic volume reductions in an ovine model of MI. Sheep-specific simulations of the cardiac cycle were performed using both incompressible and compressible tissue material models, and with synchronous or measurement-guided contraction. The compressible tissue model with measurement-guided contraction gave best agreement with experimentally measured reductions in tissue volume at peak systole, ventricular kinematics, and wall thickness changes. The incompressible model predicted myofiber peak contractile stresses approximately double the compressible model (182.8 kPa, 107.4 kPa respectively). Compensatory changes in remaining normal myocardium with MI present required less increase of contractile stress in the compressible model than the incompressible model (32.1%, 53.5%, respectively). The compressible model therefore provided more accurate representation of ventricular kinematics and potentially more realistic computed active contraction levels in the simulated infarcted heart. Our findings suggest that myocardial compressibility should be incorporated into future cardiac models for improved accuracy.
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