Evidence map›Paper›PMID 34188065›Full record

ArticleScientific reports2021

Biomedical potential of Anabaena variabilis NCCU-441 based Selenium nanoparticles and their comparison with commercial nanoparticles.

Bushra Afzal, Durdana Yasin, Haleema Naaz, Neha Sami, Almaz Zaki, Moshahid Alam Rizvi, Raj Kumar, Pooja Srivastava, Tasneem Fatma

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bushra AfzalDepartment of Biosciences, Jamia Millia Islamia (Central University), New Delhi, 110025, India.
Durdana YasinDepartment of Biosciences, Jamia Millia Islamia (Central University), New Delhi, 110025, India.
Haleema NaazDepartment of Biosciences, Jamia Millia Islamia (Central University), New Delhi, 110025, India.
Neha SamiDepartment of Biosciences, Jamia Millia Islamia (Central University), New Delhi, 110025, India.
Almaz ZakiDepartment of Biosciences, Jamia Millia Islamia (Central University), New Delhi, 110025, India.
Moshahid Alam RizviDepartment of Biosciences, Jamia Millia Islamia (Central University), New Delhi, 110025, India.
Raj KumarInstitute of Nuclear Medicine and Allied Sciences (INMAS), Defence Research and Development Organization (DRDO), New Delhi, 110054, India.
Pooja SrivastavaInstitute of Nuclear Medicine and Allied Sciences (INMAS), Defence Research and Development Organization (DRDO), New Delhi, 110054, India.
Tasneem FatmaDepartment of Biosciences, Jamia Millia Islamia (Central University), New Delhi, 110025, India. fatma_cbl@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selenium nanoparticles (SeNPs) are gaining importance in the field of medicines due to their high surface area and unique properties than their other forms of selenium. In this study, biogenic selenium nanoparticles (B-SeNPs) were synthesized using cyanobacteria and their bioactivities (antioxidant, antimicrobial, anticancer and biocompatibility) were determined for comparison with commercially available chemically synthesized selenium nanoparticles (C-SeNPs). Color change of reaction mixture from sky blue to orange-red indicated the synthesis of biogenic SeNPs (B-SeNPs). UV-Vis spectra of the reaction mixture exhibited peak at 266 nm. During optimization, 30 °C of temperature, 24 h of time and 1:2 concentration ratio of sodium selenite and cell extract represented the best condition for SeNPs synthesis. Various functional groups and biochemical compounds present in the aqueous extract of Anabaena variabilis NCCU-441, which may have possibly influenced the reduction process of SeNPs were identified by FT-IR spectrum and GC-MS. The synthesized cyanobacterial SeNPs were orange red in color, spherical in shape, 10.8 nm in size and amorphous in nature. The B-SeNPs showed better anti-oxidant (DPPH, FRAP, SOR and ABTS assays), anti-microbial (antibacterial and antifungal) and anti-cancer activitities along with its biocompatibility in comparison to C-SeNPs suggesting higher probability of their biomedical application.

Indexed as

AntioxidantsAnabaena variabilisMetal NanoparticlesSeleniumAntioxidantsSelenium

Identifiers

PMID34188065
PMCPMC8242014

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.