ArticleNPJ Parkinson's disease2021
Impaired reach-to-grasp kinematics in parkinsonian patients relates to dopamine-dependent, subthalamic beta bursts.
Article in NPJ Parkinson's disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Role of the subthalamic nucleus in motor control.Neural regeneration research · 2026Article
- Natural Frequencies of Levodopa-Induced Dyskinesia in Parkinson's Disease.Annals of clinical and translational neurology · 2026Article
- Chronic adaptive deep brain stimulation in Parkinson's disease: ADAPT-START findings and programming principles.NPJ Parkinson's disease · 2026Article
- Transformer-based long-term predictor of subthalamic beta activity in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Spike-phase coupling of subthalamic neurons to posterior perisylvian cortex predicts speech sound accuracy.Nature communications · 2025Article
- A novel biomechanical model of the proximal mouse forelimb predicts muscle activity in optimal control simulations of reaching movements.Journal of neurophysiology · 2025Article
- A comprehensive approach to studying motor planning and execution using 3D-printed objects and motion tracking technology.Frontiers in human neuroscience · 2025Article
- Adaptive vs. Conventional Deep Brain Stimulation: One-Year Subthalamic Recordings and Clinical Monitoring in a Patient with Parkinson's Disease.Bioengineering (Basel, Switzerland) · 2024Article
- Validation and application of computer vision algorithms for video-based tremor analysis.NPJ digital medicine · 2024Article
- Gait-related beta-gamma phase amplitude coupling in the subthalamic nucleus of parkinsonian patients.Scientific reports · 2024Article
- A machine learning approach for real-time cortical state estimation.Journal of neural engineering · 2024Article
- Case report: Improvement of gait with adaptive deep brain stimulation in a patient with Parkinson's disease.Frontiers in bioengineering and biotechnology · 2024Article
- Dopamine depletion leads to pathological synchronization of distinct basal ganglia loops in the beta band.PLoS computational biology · 2023Article
- Review
- A Markov random field model-based approach for differentially expressed gene detection from single-cell RNA-seq data.Briefings in bioinformatics · 2022Article
- Reaching and Grasping Movements in Parkinson's Disease: A Review.Journal of Parkinson's disease · 2022Review
- Combined Subthalamic and Nigral Stimulation Modulates Temporal Gait Coordination and Cortical Gait-Network Activity in Parkinson's Disease.Frontiers in human neuroscience · 2022Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excessive beta-band oscillations in the subthalamic nucleus are key neural features of Parkinson's disease. Yet the distinctive contributions of beta low and high bands, their dependency on striatal dopamine, and their correlates with movement kinematics are unclear. Here, we show that the movement phases of the reach-to-grasp motor task are coded by the subthalamic bursting activity in a maximally-informative beta high range. A strong, three-fold correlation linked beta high range bursts, imbalanced inter-hemispheric striatal dopaminergic tone, and impaired inter-joint movement coordination. These results provide new insight into the neural correlates of motor control in parkinsonian patients, paving the way for more informative use of beta-band features for adaptive deep brain stimulation devices.
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