ArticleNature communications2021
Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Placental ferroptosis and impaired fetal growth in symptomatic and asymptomatic SARS-CoV-2 infections.Clinical science (London, England : 1979) · 2026Article
- Halofuginone suppresses hepcidin by a heparan sulfate-dependent mechanism to treat iron disorders in mice.Blood advances · 2026Article
- [Recent advances in the management of iron deficiency and iron deficiency anemia during pregnancy].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2026Review
- Organic Iron Supplementation in Cows and Its Impacts on Animal Health and Production.Animals : an open access journal from MDPI · 2025Article
- Transgenic augmentation of erythroferrone in mice ameliorates anemia in adenine-induced chronic kidney disease.JCI insight · 2025Article
- Excessive Iron Induces Macrophage Dysfunction in the Liver, Causing Adverse Pregnancy Outcomes in Mice.Metabolites · 2025Article
- Article
- Iron Homeostasis During Pregnancy: Maternal, Placental, and Fetal Regulatory Mechanisms.Annual review of nutrition · 2023Review
- Correlation between high serum ferritin levels and adverse pregnancy outcomes in women with gestational diabetes mellitus.Heliyon · 2023Article
- Proteomic study on the lymphocytes from pregnant Wistar rat females treated with immunosuppressive regimen.Clinical and translational science · 2023Article
- Iron Deprivation by Oral Deferoxamine Application Alleviates Acute Campylobacteriosis in a Clinical MurineBiomolecules · 2022Article
- HMOX1 Promotes Ferroptosis in Mammary Epithelial Cells via FTH1 and Is Involved in the Development of Clinical Mastitis in Dairy Cows.Antioxidants (Basel, Switzerland) · 2022Article
- Erythroferrone contributes to iron mobilization for embryo erythropoiesis in iron-deficient mouse pregnancies.American journal of hematology · 2022Article
- Critical Role for Cap-Independent c-MYC Translation in Progression of Multiple Myeloma.Molecular cancer therapeutics · 2022Article
- Review
- Inhibition of Heme Oxygenase-1 by Zinc Protoporphyrin IX Improves Adverse Pregnancy Outcomes in Malaria During Early Gestation.Frontiers in immunology · 2022Article
- Association of low birthweight and small for gestational age with maternal ferritin levels: A retrospective cohort study in China.Frontiers in nutrition · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Iron is essential for a healthy pregnancy, and iron supplementation is nearly universally recommended, regardless of maternal iron status. A signal of potential harm is the U-shaped association between maternal ferritin, a marker of iron stores, and risk of adverse pregnancy outcomes. However, ferritin is also induced by inflammation and may overestimate iron stores during inflammation or infection. In this study, we use mouse models to determine whether maternal iron loading, inflammation, or their interaction cause poor pregnancy outcomes. Only maternal exposure to both iron excess and inflammation, but not either condition alone, causes embryo malformations and demise. Maternal iron excess potentiates embryo injury during both LPS-induced acute inflammation and obesity-induced chronic mild inflammation. The adverse interaction depends on TNFα signaling, causes apoptosis of placental and embryo endothelium, and is prevented by anti-TNFα or antioxidant treatment. Our findings raise important questions about the safety of indiscriminate iron supplementation during pregnancy.
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