ArticleNature communications2021
Cnidarian-bilaterian comparison reveals the ancestral regulatory logic of the β-catenin dependent axial patterning.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Reconstructing the evolutionary origin of β-catenin recognition in the Wnt destruction complex.Molecular biology and evolution · 2026Article
- A blastoporal organizer in a ctenophore.Nature · 2026Article
- Notch coordinates self-organization of germ layers and axial polarity in sea anemone gastruloids.Nature communications · 2026Article
- The anti-neural role of BMP signaling is a consequence of its ancestral function in dorsoventral patterning.PLoS biology · 2026Article
- Wnt signaling patterns a central-peripheral body axis in the early-diverging metazoan Trichoplax adhaerens.Molecular biology and evolution · 2026Article
- NvashA function reveals temporal differences in neural subtype generation in cnidarians.Scientific reports · 2026Article
- Decoding cnidarian cell type gene regulation.Nature ecology & evolution · 2026Article
- Article
- Developmental system drift and modular gene regulatory networks shape gastrulation inLife science alliance · 2025Article
- Segregation of endoderm and mesoderm germ layer identities in the diploblast Nematostella vectensis.Nature communications · 2025Article
- β-catenin-driven endomesoderm specification is a Bilateria-specific novelty.Nature communications · 2025Article
- An ancient apical patterning system sets the position of the forebrain in chordates.Science advances · 2025Article
- A transphyletic study of metazoan β-catenin protein complexes.Zoological letters · 2024Article
- Highly conserved and extremely evolvable: BMP signalling in secondary axis patterning of Cnidaria and Bilateria.Development genes and evolution · 2024Review
- Updated single cell reference atlas for the starlet anemone Nematostella vectensis.Frontiers in zoology · 2024Article
- Analysis of SMAD1/5 target genes in a sea anemone reveals ZSWIM4-6 as a novel BMP signaling modulator.eLife · 2024Article
- Evolutionarily conserved Wnt/Sp5 signaling is critical for anterior-posterior axis patterning in sea urchin embryos.iScience · 2024Article
- Gene Regulatory Network that Shaped the Evolution of Larval Apical Organ in Cnidaria.Molecular biology and evolution · 2024Article
- The evolutionary history of Brachyury genes in Hydrozoa involves duplications, divergence, and neofunctionalization.Scientific reports · 2023Article
- The brain regulatory program predates central nervous system evolution.Scientific reports · 2023Article
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10 authors.
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Abstract
In animals, body axis patterning is based on the concentration-dependent interpretation of graded morphogen signals, which enables correct positioning of the anatomical structures. The most ancient axis patterning system acting across animal phyla relies on β-catenin signaling, which directs gastrulation, and patterns the main body axis. However, within Bilateria, the patterning logic varies significantly between protostomes and deuterostomes. To deduce the ancestral principles of β-catenin-dependent axial patterning, we investigate the oral-aboral axis patterning in the sea anemone Nematostella-a member of the bilaterian sister group Cnidaria. Here we elucidate the regulatory logic by which more orally expressed β-catenin targets repress more aborally expressed β-catenin targets, and progressively restrict the initially global, maternally provided aboral identity. Similar regulatory logic of β-catenin-dependent patterning in Nematostella and deuterostomes suggests a common evolutionary origin of these processes and the equivalence of the cnidarian oral-aboral and the bilaterian posterior-anterior body axes.
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