ArticleNature communications2021
Fast and strong amplifiers of natural selection.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Environment heterogeneity creates fast amplifiers of natural selection in graph-structured populations.Nature communications · 2026Article
- Article
- Promoters of cooperation in evolutionary games.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Behavioral alignment in social networks.National science review · 2025Article
- Maintaining diversity in structured populations.PNAS nexus · 2025Article
- Colonization times in Moran process on graphs.PLoS computational biology · 2025Article
- Graph-structured populations elucidate the role of deleterious mutations in long-term evolution.Nature communications · 2025Article
- Density amplifiers of cooperation for spatial games.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Fixation times on directed graphs.PLoS computational biology · 2024Article
- The speed of neutral evolution on graphs.Journal of the Royal Society, Interface · 2024Article
- Amplifiers of selection for the Moran process with both Birth-death and death-Birth updating.PLoS computational biology · 2024Article
- Evolutionary graph theory beyond pairwise interactions: Higher-order network motifs shape times to fixation in structured populations.PLoS computational biology · 2024Article
- Experimental evidence that network topology can accelerate the spread of beneficial mutations.Evolution letters · 2023Article
- Frequent asymmetric migrations suppress natural selection in spatially structured populations.PNAS nexus · 2023Article
- Evolutionary dynamics of mutants that modify population structure.Journal of the Royal Society, Interface · 2023Article
- Fixation dynamics on hypergraphs.PLoS computational biology · 2023Article
- Self-loops in evolutionary graph theory: Friends or foes?PLoS computational biology · 2023Article
- Spectral dynamics of guided edge removals and identifying transient amplifiers for death-Birth updating.Journal of mathematical biology · 2023Article
- Agent-based methods facilitate integrative science in cancer.Trends in cell biology · 2023Review
- Suppressors of fixation can increase average fitness beyond amplifiers of selection.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Selection and random drift determine the probability that novel mutations fixate in a population. Population structure is known to affect the dynamics of the evolutionary process. Amplifiers of selection are population structures that increase the fixation probability of beneficial mutants compared to well-mixed populations. Over the past 15 years, extensive research has produced remarkable structures called strong amplifiers which guarantee that every beneficial mutation fixates with high probability. But strong amplification has come at the cost of considerably delaying the fixation event, which can slow down the overall rate of evolution. However, the precise relationship between fixation probability and time has remained elusive. Here we characterize the slowdown effect of strong amplification. First, we prove that all strong amplifiers must delay the fixation event at least to some extent. Second, we construct strong amplifiers that delay the fixation event only marginally as compared to the well-mixed populations. Our results thus establish a tight relationship between fixation probability and time: Strong amplification always comes at a cost of a slowdown, but more than a marginal slowdown is not needed.
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