ArticleNature communications2021
Dynamic causal brain circuits during working memory and their functional controllability.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Methylphenidate Enhances Spontaneous Fluctuations in Reward and Cognitive Control Networks in Children With Attention-Deficit/Hyperactivity Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Trial
- Integrating EEG and fMRI in naturalistic paradigms: Advances in understanding mental disorders-a decade study in review (2014-2024).Dialogues in clinical neuroscience · 2026Review
- Age of Onset, Brain Controllability, and Working Memory Performance in First-Episode Schizophrenia.Schizophrenia bulletin · 2026Article
- Converging on control: Rethinking treatment-resistant depression through network neuroscience.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Brain network dysfunction and treatment-induced network reorganization in major depressive disorder.Brain imaging and behavior · 2026Article
- Gut-brain health effects of PREbiotics in older adults with suspected COgnitive DEcline: design of the PRECODE randomised placebo-controlled trial.Frontiers in nutrition · 2026Article
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- Effective Connectivity Alterations of Directed Brain Network in Pediatric Patients With Spinal Cord Injury.CNS neuroscience & therapeutics · 2025Article
- Prioritizing flexible working memory representations relies on the involvement of the parahippocampal-insula network during memory reactivation.Communications biology · 2025Article
- Network localization of genetic risk for schizophrenia and bipolar disorder.Psychological medicine · 2025Article
- Abnormal Enhanced Gamma Synchronization in the Default Mode Network Associated With Chronic Pain.European journal of neurology · 2025Article
- Using an ordinary differential equation model to separate rest and task signals in fMRI.Nature communications · 2025Article
- Tracking causal pathways in TMS-evoked brain responses.PLoS computational biology · 2025Article
- Exploration of working memory retrieval stage for mild cognitive impairment: time-varying causality analysis of electroencephalogram based on dynamic brain networks.Journal of neuroengineering and rehabilitation · 2025Article
- Reduced temporal and spatial stability of neural activity patterns predict cognitive control deficits in children with ADHD.Nature communications · 2025Article
- Characterization of Neural Network Connectivity and Modularity of Pigeon Nidopallium Caudolaterale During Target Detection.Animals : an open access journal from MDPI · 2025Article
- Gyral peak variations between HCP and CHCP: functional and structural implications.Brain structure & function · 2025Article
- Dynamic network features of functional and structural brain networks support visual working memory in aging adults.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Fostering experiential learning of neurocognitive skills in brain injury tele-rehabilitation: bridging gaps in remote training by integrating scenario-based digital experiences with coaching.Frontiers in human neuroscience · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Control processes associated with working memory play a central role in human cognition, but their underlying dynamic brain circuit mechanisms are poorly understood. Here we use system identification, network science, stability analysis, and control theory to probe functional circuit dynamics during working memory task performance. Our results show that dynamic signaling between distributed brain areas encompassing the salience (SN), fronto-parietal (FPN), and default mode networks can distinguish between working memory load and predict performance. Network analysis of directed causal influences suggests the anterior insula node of the SN and dorsolateral prefrontal cortex node of the FPN are causal outflow and inflow hubs, respectively. Network controllability decreases with working memory load and SN nodes show the highest functional controllability. Our findings reveal dissociable roles of the SN and FPN in systems control and provide novel insights into dynamic circuit mechanisms by which cognitive control circuits operate asymmetrically during cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.