ArticleSaudi medical journal2021
Hemoglobinopathies: An update on the prevalence trends in Southern Saudi Arabia.
Article in Saudi medical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Frequency of Alloimmunization in Patients on Regular Blood Transfusion in Riyadh, Saudi Arabia: A Multicenter Retrospective Study.Journal of clinical medicine · 2026Article
- Mental Resilience, Satisfaction from Life, and Quality of Life of People with Hemoglobinopathies : Quality of Life of People with Haemoglobinopathies.Advances in experimental medicine and biology · 2026Article
- Distribution of Hemoglobinopathy Disorders in Al-Kharj Province Based on Data from the Premarital Screening and Genetic Counseling Program.Medicina (Kaunas, Lithuania) · 2025Article
- Prevalence and Demographic Analysis of Hemoglobinopathies in Newborns: A Three-Year Study at Thumbay Teaching Hospital, Ajman-UAE.Journal of blood medicine · 2025Article
- Relationship between hemoglobinopathies and male infertility: a scoping review.International journal of hematology · 2024Article
- Exploring experiences of mothers of children with thalassemia major in Indonesia: A descriptive phenomenological study.Belitung nursing journal · 2024Article
- Ocular Biometric Findings in Thalassemia Major: A Systematic Review and Meta-Analysis.Journal of current ophthalmologyReview
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate trends in hemoglobinopathies following the establishment of a mandatory premarital screening program (MPMSP) in the southern region of Saudi Arabia, where they are considered highly predominant.
methodsA retrospective analysis was performed on data from 32,130 high-performance liquid chromatography (HPLC) tests between November 2017 and October 2020. The data was obtained from the Hematology section, Laboratory Department, Armed Forces Hospital, Southern Region.
resultsDespite the establishment of the MPMSP, our data showed that sickle cell disease remains a predominant hemoglobinopathy accounting for more than 7% of total tests in Southern Saudi Arabia. Observed HPLC hemoglobin fractions among the tested population showed a reduction in Hb A mean indicating a high rate of hemoglobin abnormalities. In addition, the prevalence of hemoglobin variants, including sickle cell and thalassemia, was higher in the younger population born after the MPMSP than in older subjects.
conclusionEven with the implementation of the MPMSP, hemoglobin abnormalities remain prevalent in southern Saudi Arabia. A longer time frame is recommended to verify the validity of the program.
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