Evidence map›Paper›PMID 34187896›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in

Kyle S Skalenko, Lingting Li, Yuanchao Zhang, Irina O Vvedenskaya, Jared T Winkelman, Alexander L Cope, Deanne M Taylor, Premal Shah, Richard H Ebright, Justin B Kinney and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Molecular insight into 5' RNA capping with NpNature chemical biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Gauge fixing for sequence-function relationships.PLoS computational biology · 2025
    Article
  6. Article
  7. Article
  8. Gauge fixing for sequence-function relationships.bioRxiv : the preprint server for biology · 2024
    Article
  9. Article
  10. Review
  11. RNA polymerase spoiled for choice as transcription begins.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Kyle S SkalenkoDepartment of Genetics, Rutgers University, Piscataway, NJ 08854.ORCID 0000-0002-1730-0398
Lingting LiKey Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Yuanchao ZhangDepartment of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, PA 19041.
Irina O VvedenskayaDepartment of Genetics, Rutgers University, Piscataway, NJ 08854.ORCID 0000-0002-1394-4188
Jared T WinkelmanDepartment of Genetics, Rutgers University, Piscataway, NJ 08854.
Alexander L CopeDepartment of Genetics, Rutgers University, Piscataway, NJ 08854.
Deanne M TaylorDepartment of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, PA 19041.
Premal ShahDepartment of Genetics, Rutgers University, Piscataway, NJ 08854.
Richard H EbrightWaksman Institute, Rutgers University, Piscataway, NJ 08854.ORCID 0000-0001-8915-7140
Justin B KinneySimons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.ORCID 0000-0003-1897-3778
Yu ZhangKey Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Bryce E NickelsDepartment of Genetics, Rutgers University, Piscataway, NJ 08854; bnickels@waksman.rutgers.edu.ORCID 0000-0001-7449-8831
Rutgers, The State University of New Jersey · USChildren's Hospital of Philadelphia · USChinese Academy of Sciences · CNCold Spring Harbor Laboratory · US

Funding

Transcription: Mechanism and RegulationR35GM118059 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI NICKELS, BRYCE EDWARD · 2016 to 2025
$7.1M
TRANSCRIPTION ACTIVATION BY CAPR01GM041376 · NIGMS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI RICHARD H. EBRIGHT · 1989 to 2026
$6.5M
BACTERIAL TRANSCRIPTION COMPLEXESR37GM041376 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI EBRIGHT, RICHARD H. · 2013 to 2022
$5.0M
Biophysical modeling of cis-regulatory complexes in transcription and splicing using massively parallel reporter assaysR35GM133777 · NIGMS · COLD SPRING HARBOR LABORATORY · PI KINNEY, JUSTIN B. · 2019 to 2023
$2.4M
Dynamics and evolution of translational regulationR35GM124976 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI SHAH, PREMAL R · 2017 to 2021
$1.9M
NIGMS NIH HHS R01 GM041376NIGMS NIH HHS R35 GM118059NIGMS NIH HHS R35 GM124976NIGMS NIH HHS R35 GM133777NIGMS NIH HHS R37 GM041376
6 · The paper itself

Abstract

Chemical modifications of RNA 5'-ends enable "epitranscriptomic" regulation, influencing multiple aspects of RNA fate. In transcription initiation, a large inventory of substrates compete with nucleoside triphosphates for use as initiating entities, providing an ab initio mechanism for altering the RNA 5'-end. In

Indexed as

Promoter Regions, GeneticTranscription Initiation, GeneticBase SequenceBinding SitesChromosomes, BacterialDNA PrimersEscherichia coliGene Expression Regulation, BacterialRNA, MessengerTranscription Initiation SiteDNA PrimersRNA, MessengernanoRNAprimerpromoterRNA modificationRNA polymerase

Identifiers

PMID34187896
PMCPMC8271711
OpenAlexW3173465226

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.