ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2021
Periodontal Disease and Breast Cancer Risk: Results from the Nurses' Health Study.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Periodontal Disease and Incidence of Cancers: A Systematic Review and Meta-analysis of Cohort Studies.International dental journal · 2026Pooled it
- Causal association between periodontitis and systemic diseases: a systematic review and meta-analysis of mendelian randomization studies.BMC oral health · 2026Pooled it
- Modifiable and Nonmodifiable Risk Factors for Breast Cancer: A Comprehensive Scoping Review.International journal of breast cancer · 2026Review
- Oral microbiome and postmenopausal breast cancer risk: findings from the NIH-AARP diet and health study.Journal of oral microbiology · 2026Article
- Association of Periodontal Disease and Tooth Loss with Cancer in Korean Adults: A Nationwide Cross-Sectional Study.Oral health & preventive dentistry · 2025Article
- Association between periodontitis and breast cancer: two-sample Mendelian randomization study.Clinical oral investigations · 2023Observational
- The association between poor oral health and risk of breast cancer in the UK Biobank.Cancer causes & control : CCC · 2023Article
- Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundWhile periodontal disease has been linked to increased cancer risk, studies regarding an association with breast cancer are limited.
methodsWe examined the relationship between self-reported diagnosis of periodontal bone loss and incidence of breast cancer in a large, prospective cohort study, the Nurses' Health Study (1998-2014). We calculated HRs using Cox proportional hazards modeling, adjusting for risk factors common to both periodontal disease and breast cancer.
resultsDuring 1,023,647 person-years of follow-up, 5,110 of breast cancer cases were reported. We observed no association between periodontal disease and overall breast cancer risk (HR, 1.02; 95% confidence interval: 0.94-1.10); the association was not modified by smoking status, or other breast cancer risk factors or by breast tumor subtypes.
conclusionsWe did not observe any association between periodontal disease and breast cancer risk. IMPACT: Given inconsistent findings in the literature, further research with standardized clinical measures of periodontitis is warranted.
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