Trial reportDiabetes care2021
Effects of Fluid Rehydration Strategy on Correction of Acidosis and Electrolyte Abnormalities in Children With Diabetic Ketoacidosis.
Trial report in Diabetes care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07205562 (Serum Electrolyte Abnormalities as Prognostic Factor for Outcome in Critically Ill Children), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Serum Electrolyte Abnormalities as Prognostic Factor for Outcome in Critically Ill Children
Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Therapeutic value of continuous subcutaneous insulin infusion with electrolyte supplementation for pediatric diabetic ketoacidosis.European journal of pediatrics · 2026Trial
- Fluid regimens for diabetic ketoacidosis in children and adolescents: systematic review and meta-analysis.Journal of the Endocrine Society · 2026Review
- Acute kidney injury in children and adolescents with diabetic ketoacidosis managed with aggressive initial volume resuscitation.Clinics (Sao Paulo, Brazil) · 2026Article
- Balanced crystalloids versus normal saline for initial fluid resuscitation in diabetic ketoacidosis: a systematic review and meta-analysis of randomized controlled trials.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026Review
- The incidence of cerebral edema in pediatric patients with diabetic ketoacidosis: a retrospective study.BMC research notes · 2025Article
- Hyperglycemic Crises in Adults With Diabetes: A Consensus Report.Diabetes care · 2024Review
- Hyperglycaemic crises in adults with diabetes: a consensus report.Diabetologia · 2024Article
- Revised one-bag IV fluid protocol for pediatric DKA: a feasible approach and retrospective comparative study.Journal of tropical pediatrics · 2024Article
- Mitochondrial proteins as therapeutic targets in diabetic ketoacidosis: evidence from Mendelian randomization analysis.Frontiers in pharmacology · 2024Article
- The role of anion gap normalization time in the management of pediatric diabetic ketoacidosis.Frontiers in pediatrics · 2023Article
- Case Report: Diabetic Ketoacidosis During Pregnancy Due to Insulin Omission.Open access emergency medicine : OAEM · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 13 institutions in 1 country.
Funding
Abstract
objectiveFluid replacement to correct dehydration, acidosis, and electrolyte abnormalities is the cornerstone of treatment for diabetic ketoacidosis (DKA), but little is known about optimal fluid infusion rates and electrolyte content. The objective of this study was to evaluate whether different fluid protocols affect the rate of normalization of biochemical derangements during DKA treatment. RESEARCH DESIGN AND
methodsThe current analysis involved moderate or severe DKA episodes (
resultsThe rate of change of pH did not differ by treatment arm, but Pco
conclusionsIn children treated for DKA, faster fluid administration rates led to a more rapid normalization of anion gap and Pco
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.