Evidence map›Paper›PMID 34187833›Full record

ArticleBMJ open2021

Rationale and design of the Prevent Anal Cancer Self-Swab Study: a protocol for a randomised clinical trial of home-based self-collection of cells for anal cancer screening.

Alan G Nyitray, Vanessa Schick, Michael D Swartz, Anna R Giuliano, Maria E Fernandez, Ashish A Deshmukh, Timothy J Ridolfi, Christopher Ajala, Bridgett Brzezinski, Micaela Sandoval and 3 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03489707 (Annual Anal Sampling Using DNA Screening to Identify Men Who Have Sex With Men at Increased Risk for Anal Cancer), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03489707 nacompletednot on this map

Annual Anal Sampling Using DNA Screening to Identify Men Who Have Sex With Men at Increased Risk for Anal Cancer

TypeinterventionalSponsorMedical College of WisconsinRan2020 to 2023Enrolled253ConditionsAnal CancerArmsHome-based human papillomavirus (HPV) DNA screening, Clinic-based human papillomavirus (HPV) DNA screening
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Alan G NyitrayClinical Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA anyitray@mcw.edu.ORCID 0000-0003-2020-9904
Vanessa SchickDepartment of Management, Policy, and Community Health, The University of Texas Health Science Center at Houston School of Public Health, Houston, Texas, USA.
Michael D SwartzDepartment of Biostatistics and Data Science, The University of Texas Health Science Center at Houston School of Public Health, Houston, Texas, USA.
Anna R GiulianoCenter for Immunization and Infection Research in Cancer, H Lee Moffitt Cancer Center and Research Insitute, Tampa, Florida, USA.
Maria E FernandezDepartment of Health Promotion and Behavioral Sciences, The University of Texas Health Science Center at Houston School of Public Health, Houston, Texas, USA.
Ashish A DeshmukhDepartment of Management, Policy, and Community Health, The University of Texas Health Science Center at Houston School of Public Health, Houston, Texas, USA.
Timothy J RidolfiDepartment of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Christopher AjalaCenter for AIDS Intervention Research, Department of Psychiatry and Behavioural Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Bridgett BrzezinskiCenter for AIDS Intervention Research, Department of Psychiatry and Behavioural Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Micaela SandovalDepartment of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health, Houston, Texas, USA.
Belinda NedjaiWolfson Institute of Preventive Medicine, Centre for Cancer Prevention, Queen Mary University of London, London, UK.
Jennifer S SmithUniversity of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, USA.
Elizabeth Y ChiaoDepartment Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
The University of Texas Health Science Center at Houston · USMedical College of Wisconsin · USMoffitt Cancer Center · USQueen Mary University of London · GBThe University of Texas MD Anderson Cancer Center · USUniversity of North Carolina at Chapel Hill · US

Funding

Annual anal sampling using DNA screening to identify men who have sex with men at increased risk for anal cancerR01CA215403 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI NYITRAY, ALAN GASPAR · 2017 to 2021
$2.8M
NCI NIH HHS R01 CA215403
6 · The paper itself

Abstract

introductionSquamous cell carcinoma of the anus is a common cancer among sexual minority men, especially HIV-positive sexual minority men; however, there is no evidenced-based national screening protocol for detection of anal precancers. Our objective is to determine compliance with annual anal canal self-sampling or clinician-sampling for human papillomavirus (HPV) DNA. METHODS AND ANALYSIS: This is a prospective, randomised, two-arm clinical study to evaluate compliance with annual home-based versus clinic-based HPV DNA screening of anal canal exfoliated cells. The setting is primary care community-based clinics. Recruitment is ongoing for 400 HIV-positive and HIV-negative sexual minority men and transgender persons, aged ETHICS AND DISSEMINATION: The study has been approved by the Medical College of Wisconsin Human Protections Committee. Results will be disseminated to communities where recruitment occurred and through peer-reviewed literature and conferences. TRIAL REGISTRATION NUMBER: NCT03489707.

Indexed as

Anus NeoplasmsPapillomavirus InfectionsPharmaceutical PreparationsAnal CanalEarly Detection of CancerHomosexuality, MaleHumansMaleProspective StudiesRandomized Controlled Trials as TopicWisconsinPharmaceutical Preparationsepidemiologygastrointestinal tumoursHIV & AIDSpreventive medicinepublic health

Identifiers

PMID34187833
PMCPMC8245463
OpenAlexW3177383322

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.