Evidence map›Paper›PMID 34187702›Full record

ArticleFertility and sterility2021

Men born small for gestational age or with low birth weight do not improve their rate of reproduction over time: a Swedish population-based study.

Susanne Liffner, Marie Bladh, Elizabeth Nedstrand, Mats Hammar, Heriberto Rodriguez Martinez, Gunilla Sydsjö

Open access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in Fertility and sterility, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  5. Review
  6. Twinning during the pandemic: Evidence of selectionEvolution, medicine, and public health · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Susanne LiffnerDepartment of Biomedical and Clinical Sciences (BKV), Division of Children´s and Women´s Health (BKH)/Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden. Electronic address: susanne.m.liffner@regionostergotland.se.
Marie BladhDepartment of Biomedical and Clinical Sciences (BKV), Division of Children´s and Women´s Health (BKH)/Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.
Elizabeth NedstrandDepartment of Biomedical and Clinical Sciences (BKV), Division of Children´s and Women´s Health (BKH)/Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.
Mats HammarDepartment of Biomedical and Clinical Sciences (BKV), Division of Children´s and Women´s Health (BKH)/Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.
Heriberto Rodriguez MartinezDepartment of Biomedical and Clinical Sciences (BKV), Division of Children´s and Women´s Health (BKH)/Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.
Gunilla SydsjöDepartment of Biomedical and Clinical Sciences (BKV), Division of Children´s and Women´s Health (BKH)/Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.
Linköping University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate whether the reduced reproductive rate among men born small for gestational age (SGA) or with low birth weight (LBW) is present after up to 44 years of follow-up.

designPopulation-based register study.

settingNational registers in Sweden. PATIENT(S): All men born in Sweden between 1973 and 1993 (n = 1,045,167) followed up to 2018. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Registered fatherhood, infertility diagnoses, and fertility treatments obtained from registers up to 2018 RESULT(S): Men born SGA or with LBW have a lower chance of becoming fathers than men born with normal birth characteristics: hazard ratio (95% confidence interval) 0.91 (0.90-0.92) and 0.88 (0.86-0.90), respectively. The reduction in reproductive rate is more evident after a longer follow-up time. Men born SGA were more likely to receive a diagnosis of infertility. Sperm donation and intracytoplasmic sperm injection were more often used in men born SGA, further strengthening the hypothesis of an association between birth characteristics and male infertility. CONCLUSION(S): Men born SGA or with LBW have a lower chance of becoming fathers, but the reduction in fertility is smaller for the younger cohort. Further studies are needed to determine if this difference is maintained.

Indexed as

Infant, Low Birth WeightInfant, Small for Gestational AgeReproductionAge FactorsBirth WeightGestational AgeHumansInfant, NewbornInfant, PrematureInfertility, MaleMalePremature BirthRegistriesReproductive Techniques, AssistedRisk AssessmentRisk FactorsFetal growth retardationmale infertilitypopulation-based studypremature birthregister

Identifiers

PMID34187702
OpenAlexW3173795107

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.