Evidence map›Paper›PMID 34187609›Full record

ArticleJournal of the International Neuropsychological Society : JINS2022

Subjective Cognitive Decline and its Relation to Verbal Memory and Sex in Cognitively Unimpaired Individuals from a Colombian Cohort with Autosomal-Dominant Alzheimer's Disease.

Jairo E Martinez, Enmanuelle Pardilla-Delgado, Edmarie Guzmán-Vélez, Clara Vila-Castelar, Rebecca Amariglio, Jennifer Gatchel, Daniel C Aguirre-Acevedo, Yamile Bocanegra, Ana Baena, Eliana Henao and 5 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Associations Among Loneliness, Purpose in Life and Subjective Cognitive Decline in Ethnoracially Diverse Older Adults Living in the United States.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2023
    Article
  6. Review
  7. Article
  8. Consideration of sex and gender in Alzheimer's disease and related disorders from a global perspective.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022
    Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Jairo E MartinezDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA02129, USA.
Enmanuelle Pardilla-DelgadoDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA02129, USA.
Edmarie Guzmán-VélezDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA02129, USA.
Clara Vila-CastelarDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA02129, USA.
Rebecca AmariglioDepartment of Neurology, Center for Alzheimer Research and Treatment, Brigham, Women's Hospital, Harvard Medical School, Boston, MA02115, USA.
Jennifer GatchelDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA02129, USA.
Daniel C Aguirre-AcevedoGrupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia.
Yamile BocanegraGrupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia.
Ana BaenaGrupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia.
Eliana HenaoGrupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia.
Victoria TiradoGrupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia.
Claudia MuñozGrupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia.
Margarita Giraldo-ChicaGrupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia.
Francisco LoperaGrupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia.
Yakeel T QuirozDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA02129, USA.ORCID 0000-0001-9714-8244
Universidad de Antioquia · COHarvard University · USBrigham and Women's Hospital · US

Funding

Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Deborah L. BLACKER · 2019 to 2026
$36.5M
TRAINING IN SLEEP, CIRCADIAN &RESPIRATORY NEUROBIOLOGYT32HL007901 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Charles A Czeisler · 1998 to 2026
$18.5M
Depression and Alzheimer's Disease: CaTAUstrophy?R01AG078191 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Jennifer Rose Gatchel · 2022 to 2026
$4.0M
Relationship between tau pathology and cognitive impairment in autosomal dominant Alzheimer's diseaseR01AG054671 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI QUIROZ, YAKEEL T. · 2017 to 2021
$3.8M
Memory network dysfunction as an early marker of preclinical Alzheimer's DiseaseDP5OD019833 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI QUIROZ, YAKEEL T. · 2014 to 2018
$2.3M
Depressive symptoms in the pathogenesis of preclinical Alzheimer's DiseaseK23AG058805 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GATCHEL, JENNIFER ROSE · 2018 to 2022
$992k
Aerobic fitness as a modifier of neurodegeneration and cognitive decline in preclinical Alzheimer's diseaseK23AG061276 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GUZMÁN-VÉLEZ, EDMARIE · 2019 to 2023
$881k
NHLBI NIH HHS T32 HL007901NIA NIH HHS K23 AG058805NIA NIH HHS K23 AG061276NIA NIH HHS P30 AG062421NIA NIH HHS R01 AG054671NIA NIH HHS R01 AG078191NIH HHS DP5 OD019833
6 · The paper itself

Abstract

objectiveSubjective Cognitive Decline (SCD) may be an early indicator of risk for Alzheimer's disease (AD). Findings regarding sex differences in SCD are inconsistent. Studying sex differences in SCD within cognitively unimpaired individuals with autosomal-dominant AD (ADAD), who will develop dementia, may inform sex-related SCD variations in preclinical AD. We examined sex differences in SCD within cognitively unimpaired mutation carriers from the world's largest ADAD kindred and sex differences in the relationship between SCD and memory performance.

methodsWe included 310 cognitively unimpaired Presenilin-1 (PSEN-1) E280A mutation carriers (51% females) and 1998 noncarrier family members (56% females) in the study. Subjects and their study partners completed SCD questionnaires and the CERAD word list delayed recall test. ANCOVAs were conducted to examine group differences in SCD, sex, and memory performance. In carriers, partial correlations were used to examine associations between SCD and memory performance covarying for education.

resultsFemales in both groups had greater self-reported and study partner-reported SCD than males (all

conclusionsStudy partner-reported SCD may be a stronger indicator of memory decline in females

Indexed as

Alzheimer DiseaseCognitive DysfunctionCohort StudiesColombiaFemaleHeterozygoteHumansMaleNeuropsychological TestsSex FactorsEpisodic memoryFamilial Alzheimer’s diseaseMemory disordersPreclinical dementiaPresenilin-1Sex-differences

Identifiers

PMID34187609
PMCPMC8716677
OpenAlexW3173884670

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.