Evidence map›Paper›PMID 34187541›Full record

ArticleTrials2021

Bilateral cervical plexus block for anterior cervical spine surgery: study protocol for a randomised placebo-controlled trial.

Michael J Mulcahy, Thananchayan Elalingam, Kevin Jang, Mario D'Souza, Matthew Tait

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06490614 (Comparative Study Between Dexmedetomidine and Nalbuphine as Analgesic Adjuvants to Bupivacaine in Superficial Cervical Block for Patients Undergoing Anterior Cervical Discectomy and Fusion), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06490614 phase4unknown statusnot on this mapstarted 2024, after this paper: background citation

Comparative Study Between Dexmedetomidine and Nalbuphine as Analgesic Adjuvants to Bupivacaine in Superficial Cervical Block for Patients Undergoing Anterior Cervical Discectomy and Fusion (ACDF) Surgery A Double Blinded Randomized Trial

TypeinterventionalSponsorKasr El Aini HospitalRan2024 to 2024Enrolled30ConditionsAnterior Cervical Discectomy and Fusion (ACDF)ArmsDexmedetomidine in superficial cervical plexus block, Nalbuphine in superficial cervical plexus block
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Michael J MulcahyDepartment of Neurosurgery, Nepean Public Hospital, Sydney, Australia. mmulcahy@mqneurosurgery.com.ORCID http://orcid.org/0000-0001-9432-5516
Thananchayan ElalingamDepartment of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.
Kevin JangDepartment of Neurosurgery, Nepean Public Hospital, Sydney, Australia.
Mario D'SouzaCentral Clinical School, University of Sydney, Sydney, Australia.
Matthew TaitDepartment of Neurosurgery, Nepean Public Hospital, Sydney, Australia.
Nepean Hospital · AUMacquarie University · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere has been increasing focus to improve the quality of recovery following anterior cervical spine surgery (ACSS). Postoperative pain and nausea are the most common reasons for prolonged hospital stay and readmission after ACSS. Superficial cervical plexus block (SCPB) provides site-specific analgesia with minimal side effects, thereby improving the quality of recovery. The aim of our study was to investigate the effect bilateral cervical plexus block has on postoperative recovery in patients undergoing ACSS.

methodsThe study is a pragmatic, multi-centre, blinded, parallel-group, randomised placebo-controlled trial. 136 eligible patients (68 in each group) undergoing ACSS will be included. Patients randomised to the intervention group will have a SCPB administered under ultrasound guidance with a local anaesthetic solution (0.2% ropivacaine, 15mL); patients randomised to the placebo group will be injected in an identical manner with a saline solution. The primary outcome is the 40-item quality of recovery questionnaire score at 24 h after surgery. In addition, comparisons between groups will be made for a 24-h opioid usage and length of hospital stay. Neck pain intensity will be quantified using the numeric rating scale at 1, 3, 6 and at 24 h postoperatively. Incidence of nausea, vomiting, dysphagia or hoarseness in the first 24 h after surgery will also be measured. DISCUSSION: By conducting a blinded placebo trial, we aim to control for the bias inherently associated with a tangible medical intervention and show the true treatment effect of SCPB in ACSS. A statistically significant result will indicate an overall improved quality of recovery for patients; alternatively, if no benefit is shown, this trial will provide evidence that this intervention is unnecessary.

trial registrationClinicalTrials.gov ACTRN12619000028101. Prospectively registered on 11 January 2019 with Australia New Zealand Clinical Trials Registry.

Indexed as

Cervical Plexus BlockNerve BlockAnesthetics, LocalCervical VertebraeDouble-Blind MethodHumansMulticenter Studies as TopicPostoperative PainPragmatic Clinical Trials as TopicProspective StudiesRandomized Controlled Trials as TopicAnesthetics, LocalCervical spine surgeryPlaceboRandomised controlled trialSuperficial cervical plexus

Identifiers

PMID34187541
PMCPMC8244165
OpenAlexW3120807855

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.