Evidence map›Paper›PMID 34187517›Full record

ArticleMolecular brain2021

Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation.

Shannon L Cole, Ramesh Chandra, Maya Harris, Ishan Patel, Torrance Wang, Hyunjae Kim, Leah Jensen, Scott J Russo, Gustavo Turecki, Amy M Gancarz-Kausch and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Inducible CRISPR Epigenome Systems Mimic Cocaine Induced Bidirectional Regulation of Nab2 and Egr3.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  11. Article
  12. Article
  13. Distinct cell populations of ventral tegmental area process motivated behavior.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2022
    Review
  14. Review
  15. Role of Mitochondrial Dynamics in Cocaine's Neurotoxicity.International journal of molecular sciences · 2022
    Review
  16. From Circuits to Chromatin: The Emerging Role of Epigenetics in Mental Health.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Shannon L Cole *Department of Anatomy and Neurobiology, University of Maryland School of Medicine, HSF II Rm S265, 20 Penn Street, Baltimore, MD, 21201, USA.
Ramesh Chandra *Department of Anatomy and Neurobiology, University of Maryland School of Medicine, HSF II Rm S265, 20 Penn Street, Baltimore, MD, 21201, USA.
Maya HarrisDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, HSF II Rm S265, 20 Penn Street, Baltimore, MD, 21201, USA.
Ishan PatelDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, HSF II Rm S265, 20 Penn Street, Baltimore, MD, 21201, USA.
Torrance WangDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, HSF II Rm S265, 20 Penn Street, Baltimore, MD, 21201, USA.
Hyunjae KimDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, HSF II Rm S265, 20 Penn Street, Baltimore, MD, 21201, USA.
Leah JensenDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, HSF II Rm S265, 20 Penn Street, Baltimore, MD, 21201, USA.
Scott J RussoFishberg Department of Neuroscience and Friedman Brain Institute, Graduate School of Biomedical Sciences At the Icahn School of Medicine At Mount Sinai, New York, NY, USA.
Gustavo TureckiMcGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada.
Amy M Gancarz-KauschDepartment of Pharmacology and Toxicology, The Research Institution On Addictions, State University of New York At Buffalo, Buffalo, NY, USA.
David M DietzDepartment of Pharmacology and Toxicology, The Research Institution On Addictions, State University of New York At Buffalo, Buffalo, NY, USA.
Mary Kay LoboDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, HSF II Rm S265, 20 Penn Street, Baltimore, MD, 21201, USA. mklobo@som.umaryland.edu.
University of Maryland, Baltimore · USAllen Institute for Brain Science · USCalifornia State University, Bakersfield · USDouglas Mental Health University Institute · CAUniversity at Buffalo, State University of New York · US

Funding

Cocaine-induced mitochondrial mechanisms and molecular mediators in reward circuitryR01DA038613 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LOBO, MARY KAY · 2014 to 2025
$4.9M
NIDA NIH HHS R01 DA038613
6 · The paper itself

Abstract

Mitochondrial function is required for brain energy homeostasis and neuroadaptation. Recent studies demonstrate that cocaine affects mitochondrial dynamics and morphological characteristics within the nucleus accumbens (NAc). Further, mitochondria are differentially regulated by cocaine in dopamine receptor-1 containing medium spiny neurons (D1-MSNs) vs dopamine receptor-2 (D2)-MSNs. However, there is little understanding into cocaine-induced transcriptional mechanisms and their role in regulating mitochondrial processes. Here, we demonstrate that cocaine enhances binding of the transcription factor, early growth response factor 3 (Egr3), to nuclear genes involved in mitochondrial function and dynamics. Moreover, cocaine exposure regulates mRNA of these mitochondria-associated nuclear genes in both contingent or noncontingent cocaine administration and in both rodent models and human postmortem tissue. Interestingly, several mitochondrial nuclear genes showed distinct profiles of expression in D1-MSNs vs D2-MSNs, with cocaine exposure generally increasing mitochondrial-associated nuclear gene expression in D1-MSNs vs suppression in D2-MSNs. Further, blunting Egr3 expression in D1-MSNs blocks cocaine-enhancement of the mitochondrial-associated transcriptional coactivator, peroxisome proliferator-activated receptor gamma coactivator (PGC1α), and the mitochondrial fission molecule, dynamin related protein 1 (Drp1). Finally, reduction of D1-MSN Egr3 expression attenuates cocaine-induced enhancement of small-sized mitochondria, causally demonstrating that Egr3 regulates mitochondrial morphological adaptations. Collectively, these studies demonstrate cocaine exposure impacts mitochondrial dynamics and morphology by Egr3 transcriptional regulation of mitochondria-related nuclear gene transcripts; indicating roles for these molecular mechanisms in neuronal function and plasticity occurring with cocaine exposure.

Indexed as

Gene Expression RegulationTranscription, GeneticAdultAnimalsCell NucleusCocaineEarly Growth Response Protein 3FemaleGenes, MitochondrialHumansMaleMiceMice, Inbred C57BLMiddle AgedMitochondrial DynamicsNeuronsCocaineEarly Growth Response Protein 3RNA, MessengerCocaineD1-MSNsD2-MSNsMitochondriaNucleus accumbens

Identifiers

PMID34187517
PMCPMC8240292
OpenAlexW3175646026

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.