Evidence map›Paper›PMID 34187407›Full record

ArticleBMC public health2021

Influences on catch-up growth using relative versus absolute metrics: evidence from the MAL-ED cohort study.

Stephanie A Richard, Benjamin J J McCormick, Laura E Murray-Kolb, Pascal Bessong, Sanjaya K Shrestha, Estomih Mduma, Tahmeed Ahmed, Gagandeep Kang, Gwenyth O Lee, Jessica C Seidman and 4 more

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In one paragraph

Article in BMC public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Stephanie A RichardFogarty International Center/National Institutes of Health, Bethesda, MD, USA.
Benjamin J J McCormickFogarty International Center/National Institutes of Health, Bethesda, MD, USA.
Laura E Murray-KolbThe Pennsylvania State University, University Park, PA, USA.
Pascal BessongUniversity of Venda, Thohoyandou, South Africa.
Sanjaya K ShresthaWalter Reed, Armed Forces Research Institute of Medical Sciences (AFRIMS) Research Unit, Nepal, (WARUN), Kathmandu, Nepal.
Estomih MdumaHaydom Lutheran Hospital, Haydom, Manyara, Tanzania.
Tahmeed Ahmedicddr,b, Dhaka, Bangladesh.
Gagandeep KangDivision of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
Gwenyth O LeeThe Johns Hopkins University, 615 North Wolfe Street, Room W2041, Baltimore, MD, 21205, USA.
Jessica C SeidmanFogarty International Center/National Institutes of Health, Bethesda, MD, USA.
Erling SvensenHaukeland University Hospital, Bergen, Norway.
Margaret N KosekUniversity of Virginia, Charlottesville, VA, USA.
Laura E CaulfieldThe Johns Hopkins University, 615 North Wolfe Street, Room W2041, Baltimore, MD, 21205, USA. lcaulfi1@jhu.edu.ORCID 0000-0001-7152-1004
MAL-ED Network Investigators

Funding

Vitamin A Supplementation and Retinol Metabolism in the Neonatal PeriodR01HD066982 · NICHD · PENNSYLVANIA STATE UNIVERSITY, THE · PI ROSS, A. CATHARINE · 2010 to 2019
$2.9M
NICHD NIH HHS R01 HD066982
6 · The paper itself

Abstract

backgroundPoor growth in early childhood has been considered irreversible after 2-3 years of age and has been associated with morbidity and mortality over the short-term and with poor economic and cognitive outcomes over the long-term. The MAL-ED cohort study was performed in eight low-income settings with the goal of evaluating relationships between the child's environment and experience (dietary, illness, and pathogen exposure, among others) and their growth and development. The goal of this analysis is to determine whether there are differences in the factors associated with growth from 24 to 60 months using two different metrics.

methodsAcross six MAL-ED sites, 942 children had anthropometry data at 24 and 60 months, as well as information about socioeconomic status, maternal height, gut permeability (lactulose-mannitol z-score (LMZ)), dietary intake from 9 to 24 months, and micronutrient status. Anthropometric changes were in height- or weight-for-age z-score (HAZ, WAZ), their absolute difference from the growth standard median (HAD (cm), WAD (kg)), as well as recovery from stunting/underweight. Outcomes were modeled using multivariate regression.

resultsAt 24 months, almost half of the cohort was stunted (45%) and 21% were underweight. Among those who were stunted at 24 months (n = 426), 185 (43%) were no longer stunted at 60 months. Most children increased their HAZ from 24 to 60 months (81%), whereas fewer (33%) had positive changes in their HAD. Linear regression models indicate that girls improved less than boys from 24 to 60 months (HAZ: -0.21 (95% CI -0.27, -0.15); HAD: -0.75 (-1.07, -0.43)). Greater intestinal permeability (higher LMZ) at 0-24 months was associated with lower relative and absolute changes from 24 to 60 months (HAZ: -0.10 (-0.16, -0.04); HAD: -0.47 (-0.73, -0.21)). Maternal height (per 10 cm) was positively associated with changes (HAZ: 0.09 (0.03, 0.15); HAD: 0.45 (0.15, 0.75)). Similar relationships were identified for changes in WAZ and WAD.

conclusionsThe study children demonstrated improved growth from 24 to 60 months of age, but only a subset had positive changes in HAD and WAD. The same environmental factors were associated with growth from 24 to 60 months regardless of metric used (change in HAZ or HAD, or WAZ and WAD).

Indexed as

AnthropometryBody HeightBody WeightChildChild, PreschoolCohort StudiesFemaleGrowth DisordersHumansInfantMaleCatch-up growthEnteric dysfunctionPermeabilityStuntingUnderweight

Identifiers

PMID34187407
PMCPMC8240385

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.