Evidence map›Paper›PMID 34187349›Full record

ArticleBioengineered2021

Danshensu alleviates bleomycin-induced pulmonary fibrosis by inhibiting lung fibroblast-to-myofibroblast transition via the MEK/ERK signaling pathway.

Huaman Liu, Xinyue Zhang, Yumeng Shao, Xuehong Lin, Feng Dong, Xue Liu

Open access · goldAbstract read
In one paragraph

Article in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Huaman LiuCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Xinyue ZhangFirst College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Yumeng ShaoCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Xuehong LinDepartment of General Medicine, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Feng DongDepartment of General Medicine, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Xue LiuFirst College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Shandong University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary fibrosis (PF) is a chronic pulmonary interstitial disease, and its pathological process is closely related to fibroblast-myofibroblast differentiation. Danshensu (DSS) has been reported to exert an anti-fibrotic effect in heart and liver. However, it is unknown whether DSS has an equally anti-fibrotic effect on lungs. To evaluate the effect of DSS on PF and demonstrate its possible molecular mechanisms, we established an

Indexed as

Pulmonary FibrosisAnimalsBleomycinCell DifferentiationLactatesLungMaleMAP Kinase Signaling SystemMiceMice, Inbred C57BLMyofibroblastsNIH 3T3 Cells3,4-dihydroxyphenyllactic acidBleomycinLactatesdanshensufibroblastMEK; ERKmyofibroblasPulmonary fibrosis

Identifiers

PMID34187349
PMCPMC8806824
OpenAlexW3174798116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.