Observational studyCirculation. Cardiovascular imaging2021
Analysis of 3-Dimensional Arch Anatomy, Vascular Flow, and Postnatal Outcome in Cases of Suspected Coarctation of the Aorta Using Fetal Cardiac Magnetic Resonance Imaging.
Observational study in Circulation. Cardiovascular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 67 citations in OpenAlex.
- Fetal Echocardiography Enhances Perinatal Care for Coarctation of the Aorta: Balancing Risk of Hemodynamic Compromise and Resource Utilization.Pediatric cardiology · 2026Article
- Optimisation of an Algorithm for Fetal Strain by CMR and its Use in Suspected Coarctation of the Aorta.Pediatric cardiology · 2026Article
- Myocardial Deformation and Its Relation to Ventricular Shape, Preload, and Afterload in Fetuses with Suspected Coarctation of the Aorta.Pediatric cardiology · 2026Article
- Fetal Cardiac Deformation in Persistent Left-Sided Superior Vena Cava and Suspected Coarctation of the Aorta.Pediatric cardiology · 2026Article
- Prenatal ultrasound prediction of coarctation of the aorta: a nomogram for risk stratification.Pediatric radiology · 2025Article
- The role of magnetic resonance imaging in fetal congenital heart disease.Pediatric radiology · 2025Review
- Characterizing fetoplacental response to acute maternal hyperoxygenation in suspected coarctation of aorta using fetal cardiac MRI.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025Article
- A Novel Prenatal Pipeline for Three-Dimensional Hemodynamic Modeling of the Fetal Aorta.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Article
- Fetal Cardiovascular Magnetic Resonance: History, Current Status, and Future Directions.Journal of magnetic resonance imaging : JMRI · 2025Review
- Hypertension in aortic coarctation.Frontiers in cardiovascular medicine · 2025Review
- Three-Dimensional Ultrasound for Physical and Virtual Fetal Heart Models: Current Status and Future Perspectives.Journal of clinical medicine · 2024Review
- Structural Covariance Networks in the Fetal Brain Reveal Altered Neurodevelopment for Specific Subtypes of Congenital Heart Disease.Journal of the American Heart Association · 2024Article
- The onset of coarctation of the aorta before birth: Mechanistic insights from fetal arch anatomy and haemodynamics.Computers in biology and medicine · 2024Article
- Total and Regional Brain Volumes in Fetuses With Congenital Heart Disease.Journal of magnetic resonance imaging : JMRI · 2024Article
- Importance of Cardiovascular Magnetic Resonance Applied to Congenital Heart Diseases in Pediatric Age: A Narrative Review.Children (Basel, Switzerland) · 2024Review
- Advances in Fetal Cardiac Imaging and Intervention.CJC pediatric and congenital heart disease · 2024Review
- Non-Invasive Imaging Assessment in Patients with Aortic Coarctation: A Contemporary Review.Journal of clinical medicine · 2023Review
- Utility of Fetal Cardiac Resonance Imaging in Prenatal Clinical Practice: Current State of the Art.Diagnostics (Basel, Switzerland) · 2023Review
- The Predictive Value of the CSA Index in the Prenatal Diagnosis of Aortic Coarctation in Ultrasound Examination Performed during the Second Trimester.Journal of clinical medicine · 2023Article
- Right Ventricular Function and Right Ventricular-Vascular Coupling Assessment After Coarctation Repair in Adults.CJC pediatric and congenital heart disease · 2023Article
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIdentifying fetuses at risk of severe neonatal coarctation of the aorta (CoA) can be lifesaving but is notoriously challenging in clinical practice with a high rate of false positives. Novel fetal 3-dimensional and phase-contrast magnetic resonance imaging (MRI) offers an unprecedented means of assessing the human fetal cardiovascular system before birth. We performed detailed MRI assessment of fetal vascular morphology and flows in a cohort of fetuses with suspected CoA, correlated with the need for postnatal intervention.
methodsWomen carrying a fetus with suspected CoA on echocardiography were referred for MRI assessment between 26 and 36 weeks of gestation, including high-resolution motion-corrected 3-dimensional volumes of the fetal heart and phase-contrast flow sequences gated with metric optimized gating. The relationship between aortic geometry and vascular flows was then analyzed and compared with postnatal outcome.
resultsSeventy-two patients (51 with suspected fetal CoA and 21 healthy controls) underwent fetal MRI with motion-corrected 3-dimensional vascular reconstructions. Vascular flow measurements from phase-contrast sequences were available in 53 patients. In the CoA group, 25 of 51 (49%) required surgical repair of coarctation after birth; the remaining 26 of 51 (51%) were discharged without neonatal intervention. Reduced blood flow in the fetal ascending aorta and at the aortic isthmus was associated with increasing angulation (
conclusionsReduced blood flow though the left heart is associated with important configurational changes at the aortic isthmus in fetal life, predisposing to CoA when the arterial duct closes after birth. Novel fetal MRI techniques may have a role in both understanding and accurately predicting severe neonatal CoA.
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