Evidence map›Paper›PMID 34187104›Full record

ArticleArhiv za higijenu rada i toksikologiju2021

1,4-dihydropyridine derivatives increase mRNA expression of

Kristīne Dišlere, Evita Rostoka, Egils Bisenieks, Gunars Duburs, Natalia Paramonova, Nikolajs Sjakste

Open access · diamondAbstract read
In one paragraph

Article in Arhiv za higijenu rada i toksikologiju, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kristīne DišlereUniversity of Latvia Institute of Biology, Riga, Latvia.
Evita RostokaUniversity of Latvia Institute of Biology, Riga, Latvia.
Egils BisenieksLatvian Institute of Organic Synthesis, Riga, Latvia.
Gunars DubursLatvian Institute of Organic Synthesis, Riga, Latvia.
Natalia ParamonovaUniversity of Latvia Institute of Biology, Riga, Latvia.
Nikolajs SjaksteUniversity of Latvia Institute of Biology, Riga, Latvia.
Latvijas Organiskās Sintēzes Institūts · LVUniversity of Latvia · LV

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ubiquitin-proteasome system modifies different cellular and protein functions. Its dysregulation may lead to disrupted proteostasis associated with multiple pathologies and aging. Pharmacological regulation of proteasome functions is already an important part of the treatment of several diseases. 1,4-dihydropyridine (1,4-DHP) derivatives possess different pharmacological activities, including antiaging and neuroprotective. The aim of this study was to investigate the effects of several 1,4-DHP derivatives on mRNA expression levels of proteasomal genes

Indexed as

KidneyProteasome Endopeptidase ComplexAnimalsDihydropyridinesRatsRNA, Messenger1,4-dihydropyridineDihydropyridinesProteasome Endopeptidase ComplexPsmb5 protein, ratRNA, MessengerAV-153-CaAV-153-Naetcarbatoneetkarbatongene expressionglutapironglutapyroneimpaired proteasomal functionsmetcarbatonemetkarbatonpharmacological activitiesporemećena proteasomska funkcijaproteasome subunitsproteasomske podjedinicestirilkarbatonstyrylcarbatoneubikvitin-proteasomski sustavubiquitin-proteasome system

Identifiers

PMID34187104
PMCPMC8265202
OpenAlexW3173866493

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.