Evidence map›Paper›PMID 34186496›Full record

ArticleDNA repair2021

DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model.

Sesha L Paluri, Matthew Burak, Alireza G Senejani, Madison Levinson, Tania Rahim, Kaylyn Clairmont, Michael Kashgarian, Isabel Alvarado-Cruz, Rithy Meas, Marina Cardó-Vila and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in DNA repair, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Levels of base excision repair proteins in CD4Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 1 country.

Sesha L PaluriDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, 48824, United States.
Matthew BurakMassBiologics, Mattapan, MA, 02126, United States.
Alireza G SenejaniUniversity of New Haven, West Haven, CT, 06516, United States.
Madison LevinsonDepartment of Cellular and Molecular Medicine and University of Arizona Cancer Center, Tucson, AZ, 85724, United States.
Tania RahimDepartment of Genetics, Yale University School of Medicine, New Haven, CT, 06520, United States.
Kaylyn ClairmontDepartment of Genetics, Yale University School of Medicine, New Haven, CT, 06520, United States.
Michael KashgarianDepartment of Pathology, Yale University School of Medicine, New Haven, CT, 06520, United States.
Isabel Alvarado-CruzDepartment of Cellular and Molecular Medicine and University of Arizona Cancer Center, Tucson, AZ, 85724, United States.
Rithy MeasDepartment of Cellular and Molecular Medicine and University of Arizona Cancer Center, Tucson, AZ, 85724, United States.
Marina Cardó-VilaDepartment of Cellular and Molecular Medicine and University of Arizona Cancer Center, Tucson, AZ, 85724, United States.
Caroline ZeissDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, United States.
Stephen MaherDepartment of Immunology, Yale University School of Medicine, New Haven, CT, 06520, United States.
Alfred L M BothwellDepartment of Immunology, Yale University School of Medicine, New Haven, CT, 06520, United States.
Erdem CoskunBiomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD, 20899, United States; Institute for Bioscience & Biotechnology Research, University of Maryland, Rockville, MD, 20850, United States.
Melis KantBiomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD, 20899, United States.
Pawel JarugaBiomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD, 20899, United States.
Miral DizdarogluBiomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD, 20899, United States.
R Stephen LloydOregon Institute of Occupational Health Sciences, Oregon Health and Science University, Portland, OR, 97239, United States.
Joann B SweasyDepartment of Cellular and Molecular Medicine and University of Arizona Cancer Center, Tucson, AZ, 85724, United States. Electronic address: jsweasy@email.arizona.edu.
Yale University · USUniversity of Arizona · USNational Institute of Standards and Technology · USMichigan State University · USOregon Health & Science University · USUniversity of New Haven · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Aberrant DNA Repair and LupusR35ES031708 · NIEHS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Joann B. Sweasy · 2020 to 2026
$5.3M
DNA Polymerase Beta Variants and CancerR01ES019179 · NIEHS · YALE UNIVERSITY · PI SWEASY, JOANN B. · 2010 to 2020
$3.9M
Characterization of a DNA Polymerase Beta Deficient MouseR01CA116753 · NCI · YALE UNIVERSITY · PI SWEASY, JOANN B. · 2006 to 2016
$2.8M
NCATS NIH HHS UL1 TR001863NCI NIH HHS R01 CA116753NIEHS NIH HHS R01 ES019179NIEHS NIH HHS R35 ES031708
6 · The paper itself

Abstract

The Polb gene encodes DNA polymerase beta (Pol β), a DNA polymerase that functions in base excision repair (BER) and microhomology-mediated end-joining. The Pol β-Y265C protein exhibits low catalytic activity and fidelity, and is also deficient in microhomology-mediated end-joining. We have previously shown that the Polb

Indexed as

DNA RepairMutationOxidative StressAnimalsDisease Models, AnimalDNADNA GlycosylasesDNA Polymerase betaGene DeletionLupus Erythematosus, SystemicMiceDNADNA GlycosylasesDNA Polymerase betaNeil1 protein, mouseOgg1 protein, mouseBase excision repairDNA glycosylaseDNA polymerase betaOxidative DNA damageSystemic lupus erythematosus

Identifiers

PMID34186496
PMCPMC8635285
OpenAlexW3174426887

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.