Evidence map›Paper›PMID 34186209›Full record

ReviewClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases2021

Prevalence and factors associated with SARS-CoV-2 seropositivity in the Spanish HIV Research Network Cohort.

Juan Berenguer, Cristina Díez, María Martín-Vicente, Rafael Micán, María J Pérez-Elías, Lucio J García-Fraile, Francisco Vidal, Inés Suárez-García, Daniel Podzamczer, Jorge Del Romero and 14 more

Open access · hybridAbstract readReview
In one paragraph

Review in Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

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  19. Severe immunosuppression is related to poorer immunogenicity to SARS-CoV-2 vaccines among people living with HIV.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 18 institutions in 1 country.

Juan BerenguerHospital General Universitario Gregorio Marañón, IiSGM, Madrid, Spain. Electronic address: jbb4@me.com.
Cristina DíezHospital General Universitario Gregorio Marañón, IiSGM, Madrid, Spain.
María Martín-VicenteCentro Nacional de Microbiología (ISCIII), Majadahonda, Spain.
Rafael MicánHospital Universitario La Paz, IdiPaz, Madrid, Spain.
María J Pérez-ElíasHospital Ramón y Cajal, Universidad de Alcalá, IRYCIS, Madrid, Spain.
Lucio J García-FraileHospital Universitario de La Princesa, Madrid, Spain.
Francisco VidalHospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain.
Inés Suárez-GarcíaHospital Universitario Infanta Sofía, FIIB HUIS HHEN, San Sebastián de los Reyes, Universidad Europea de Madrid, Spain.
Daniel PodzamczerHospital Universitari de Bellvitge, Barcelona, Spain.
Jorge Del RomeroCentro Sandoval, Madrid, Spain.
Federico PulidoHospital Universitario 12 Octubre, imas12, Universidad Complutense de Madrid, Madrid, Spain.
José A IribarrenHospital Universitario Donostia, II BioDonostia, San Sebastián, Spain.
Félix GutiérrezHospital Universitario de Elche, Universidad Miguel Hernández, Elche, Spain.
Eva PovedaGalicia Sur Health Research Institute (IIS Galicia Sur)-Complexo Hospitalario Universitario de Vigo, SERGAS-UVigo, Spain.
Carlos GaleraHospital Universitario Virgen de la Arrixaca, Murcia, Spain.
Rebeca IzquierdoCentro Nacional de Epidemiología (ISCIII), Madrid, Spain.
Víctor AsensiHospital Universitario Central de Asturias, Oviedo, Spain.
Joaquín PortillaHospital General Universitario de Alicante, Alicante, Spain.
Juan C LópezHospital General Universitario Gregorio Marañón, IiSGM, Madrid, Spain.
José R ArribasHospital Universitario La Paz, IdiPaz, Madrid, Spain.
Santiago MorenoHospital Ramón y Cajal, Universidad de Alcalá, IRYCIS, Madrid, Spain.
Juan González-GarcíaHospital Universitario La Paz, IdiPaz, Madrid, Spain.
Salvador ResinoCentro Nacional de Microbiología (ISCIII), Majadahonda, Spain.
Inmaculada JarrínCentro Nacional de Epidemiología (ISCIII), Madrid, Spain.
Hospital General Universitario Gregorio Marañón · ESHospital Universitario La Paz · ESInstituto de Salud Carlos III · ESBellvitge University Hospital · ESBiogipuzkoa Health Research Institute · ESCentro Nacional de Epidemiología · ESCentro Nacional de Microbiologia · ESComplexo Hospitalario Universitario A Coruña · ESHospital General Universitario de Alicante Doctor Balmis · ESHospital Universitari Joan XXIII de Tarragona · ESHospital Universitario Central de Asturias · ESHospital Universitario de La Princesa · ESHospital Universitario Virgen de la Arrixaca · ESInstituto Ramón y Cajal de Investigación Sanitaria · ESUniversidad Complutense de Madrid · ESUniversidad de Alcalá · ESUniversidad Europea · ESUniversitat de Miguel Hernández d'Elx · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe aimed to assess the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and factors associated with seropositivity and asymptomatic coronavirus disease 2019 (COVID-19) among people with HIV (PWH).

methodsThis was a cross-sectional study carried out within the cohort of the Spanish HIV Research Network. Participants were consecutive PWH with plasma collected from 1st April to 30th September 2020. We determined SARS-CoV-2 antibodies (Abs) in plasma. Illness severity (NIH criteria) was assessed by a review of medical records and, if needed, participant interviews. Multivariable logistic regression analysis was used to identify predictors of seropositivity among the following variables: sex, age, country of birth, education level, comorbidities (hypertension, chronic heart disease, diabetes mellitus, non-AIDS-related cancer, chronic kidney disease, cirrhosis), route of HIV acquisition, prior AIDS, CD4+ cell count, HIV viral load, nucleoside/nucleotide reverse transcriptase inhibitor (N [t]RTI) backbone, type of third antiretroviral drug, and month of sample collection.

resultsOf 1076 PWH (88.0% males, median age 43 years, 97.7% on antiretroviral therapy, median CD4+ 688 cells/mm

conclusionsMany SARS-CoV-2 infections among PWH were asymptomatic, and birth in Latin American countries increased the risk of SARS-CoV-2 seropositivity. Our analysis, adjusted by comorbidities and other variables, suggests that TDF/FTC may prevent SARS-CoV-2 infection among PWH.

Indexed as

Anti-HIV AgentsCOVID-19HIV InfectionsAdultCross-Sectional StudiesEmtricitabineFemaleHumansMalePrevalenceReverse Transcriptase InhibitorsSeroepidemiologic StudiesSpainTenofovirAnti-HIV AgentsEmtricitabineReverse Transcriptase InhibitorsTenofovirCOVID-19HIVSARS-CoV-2SerologySeroprevalence

Identifiers

PMID34186209
PMCPMC8267776
OpenAlexW3177144133

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.