ArticleAnalytical chemistry2021
Absorption Mode Fourier Transform Ion Mobility Mass Spectrometry Multiplexing Combined with Half-Window Apodization Windows Improves Resolution and Shortens Acquisition Times.
Article in Analytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- UHRMS Formula Assignment: Diophantine-Based Recalibration Yields Lorentzian Mass Error Distribution as the Limiting Factor.Journal of the American Society for Mass Spectrometry · 2026Article
- Instrumentation at the Leading Edge of Proteomics.Analytical chemistry · 2024Review
- Development of a Modular, Open-Source, Reduced-Pressure, Drift Tube Ion Mobility Spectrometer.Journal of the American Society for Mass Spectrometry · 2024Article
- Nonlinear Frequency Modulation for Fourier Transform Ion Mobility Mass Spectrometry Improves Experimental Efficiency.International journal of mass spectrometry · 2024Article
- Implementation of an Open-Source Multiplexing Ion Gate Control for High Kinetic Energy Ion Mobility Spectrometry (HiKE-IMS).Journal of the American Society for Mass Spectrometry · 2023Article
- FTflow: An Open-Source Python GUI for FT-IM-MS Experiments.Journal of the American Society for Mass Spectrometry · 2023Article
- Exploring the Conformations and Binding Location of HMGA2·DNA Complexes Using Ion Mobility Spectrometry and 193 nm Ultraviolet Photodissociation Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2022Article
- Separation and Collision Cross Section Measurements of Protein Complexes Afforded by a Modular Drift Tube Coupled to an Orbitrap Mass Spectrometer.Analytical chemistry · 2022Article
- Synchronized Stepped Frequency Modulation for Multiplexed Ion Mobility Measurements.Journal of the American Society for Mass Spectrometry · 2022Article
- Implementing Digital-Waveform Technology for ExtendedJournal of the American Society for Mass Spectrometry · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Fourier transform multiplexing enables the coupling of drift tube ion mobility to a wide array of mass spectrometers with improved ion utilization and duty cycles compared to dual-gate signal averaging methods. Traditionally, the data generated by this method is presented in the magnitude mode, but significant improvements in resolution and the signal-to-noise ratio (SNR) are expected if the data can be phase corrected and presented in the absorption mode. A method to simply and reliably determine and correct phase shifts in Fourier transform ion mobility mass spectrometry data using information readily available to any user is presented and evaluated for both small molecule and intact protein analyses with no modification to instrument hardware or experimental procedures. Additionally, the effects of apodization and zero padding are evaluated for both processing methods, and a strategy to use these techniques to reduce acquisition times is presented and evaluated. Resolution is improved by an average factor of 1.6, the SNR is improved by an average factor of 1.2, and acquisition times are reduced by up to 80% through the application of absorption mode processing combined with apodization and zero padding.
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