Evidence map›Paper›PMID 34185847›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2022

Rapidly Increasing Severe Acute Respiratory Syndrome Coronavirus 2 Seroprevalence and Limited Clinical Disease in 3 Malian Communities: A Prospective Cohort Study.

Issaka Sagara, John Woodford, Mamady Kone, Mahamadoun Hamady Assadou, Abdoulaye Katile, Oumar Attaher, Amatigue Zeguime, M'Bouye Doucoure, Emily Higbee, Jacquelyn Lane and 8 more

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Trial
  2. Serological evidence of high exposure toMalariaWorld journal · 2026
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  8. Characterizing the evolving SARS-CoV-2 seroprevalence in urban and rural Malawi between February 2021 and April 2022: A population-based cohort study.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023
    Article
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  19. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Africa: Current Considerations and Future Projections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Article
  20. High SARS-CoV-2 seroprevalence among health care workers in Bamako referral hospitals: a prospective multisite cross-sectional study (ANRS COV11).Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Issaka SagaraMalaria Research and Training Center/University of Sciences, Techniques and Techniques of Bamako, Bamako, Mali.
John WoodfordLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland, Bethesda, USA.
Mamady KoneMalaria Research and Training Center/University of Sciences, Techniques and Techniques of Bamako, Bamako, Mali.
Mahamadoun Hamady AssadouMalaria Research and Training Center/University of Sciences, Techniques and Techniques of Bamako, Bamako, Mali.
Abdoulaye KatileMalaria Research and Training Center/University of Sciences, Techniques and Techniques of Bamako, Bamako, Mali.
Oumar AttaherMalaria Research and Training Center/University of Sciences, Techniques and Techniques of Bamako, Bamako, Mali.
Amatigue ZeguimeMalaria Research and Training Center/University of Sciences, Techniques and Techniques of Bamako, Bamako, Mali.
M'Bouye DoucoureMalaria Research and Training Center/University of Sciences, Techniques and Techniques of Bamako, Bamako, Mali.
Emily HigbeeLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland, Bethesda, USA.
Jacquelyn LaneLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland, Bethesda, USA.
Rathy MohanLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland, Bethesda, USA.
Justin DoritchamouLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland, Bethesda, USA.
Irfan ZaidiLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland, Bethesda, USA.
Dominic EspositoFrederick National Laboratory for Cancer Research, National Institutes of Health, Maryland, Frederick, USA.
Jennifer KwanLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland, Bethesda, USA.
Kaitlyn SadtlerNational Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Maryland, Bethesda, USA.
Alassane DickoMalaria Research and Training Center/University of Sciences, Techniques and Techniques of Bamako, Bamako, Mali.
Patrick E DuffyLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland, Bethesda, USA.

Funding

ImmunoengineeringZIAEB000093 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI SADTLER, KAITLYN · 2020 to 2025
$5.5M
COVID-19 Serosurveys and Vaccine Study Site PreparationsZIAAI001261 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DUFFY, PATRICK · 2020 to 2025
$2.4M
CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENIBIB NIH HHSNIH HHS HHSN261200800001E
6 · The paper itself

Abstract

backgroundThe extent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure and transmission in Mali and the surrounding region is not well understood. We aimed to estimate the cumulative incidence of SARS-CoV-2 in 3 communities and understand factors associated with infection.

methodsBetween July 2020 and January 2021, we collected blood samples and demographic, social, medical, and self-reported symptoms information from residents aged 6 months and older over 2 study visits. SARS-CoV-2 antibodies were measured using a highly specific 2-antigen enzyme-linked immunosorbent assay optimized for use in Mali. We calculated cumulative adjusted seroprevalence for each community and evaluated factors associated with serostatus at each visit by univariate and multivariate analysis.

resultsOverall, 94.8% (2533/2672) of participants completed both study visits. A total of 31.3% (837/2672) were aged <10 years, 27.6% (737/2672) were aged 10-17 years, and 41.1% (1098/2572) were aged ≥18 years. The cumulative SARS-CoV-2 exposure rate was 58.5% (95% confidence interval, 47.5-69.4). This varied between sites and was 73.4% in the urban community of Sotuba, 53.2% in the rural town of Bancoumana, and 37.1% in the rural village of Donéguébougou. Study site and increased age were associated with serostatus at both study visits. There was minimal difference in reported symptoms based on serostatus.

conclusionsThe true extent of SARS-CoV-2 exposure in Mali is greater than previously reported and may now approach hypothetical "herd immunity" in urban areas. The epidemiology of the pandemic in the region may be primarily subclinical and within background illness rates.

Indexed as

COVID-19MaliSARS-CoV-2seroprevalenceWest Africa

Identifiers

PMID34185847
PMCPMC8394825

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.