ArticlePloS one2021
Oral health and longitudinal changes in fasting glucose levels: A nationwide cohort study.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- How dietary interventions impact oral conditions: a systematic review.BMC oral health · 2026Pooled it
- Impact of Oral Hygiene Practices in Reducing Cardiometabolic Risk, Incidence, and Mortality: A Systematic Review.International journal of environmental research and public health · 2024Pooled it
- Associated factors of oral frailty in older adults with long-term T2DM duration of more than 10 years.BMC geriatrics · 2025Article
- Renal hyperfiltration is associated with a reduced incidence of hypertension in individuals younger than 70.Scientific reports · 2025Article
- The Association between the Triglyceride-Glucose Index and the Incidence Risk of Parkinson's Disease: A Nationwide Cohort Study.Journal of movement disorders · 2025Article
- Association between triglyceride/high density lipoprotein ratio and incidence risk of Parkinson's disease: a population-based cohort study.Scientific reports · 2025Article
- Tooth loss and mortality risk: the mediating role of hs-CRP in a Chinese cohort.Frontiers in oral health · 2025Article
- Association of renal hyperfiltration with incidence of dyslipidemia: a nationwide retrospective longitudinal cohort study.PloS one · 2025Article
- Association of Periodontal Condition With Impaired Glucose Tolerance: Results of a 15-Year Follow-Up Study.Clinical and experimental dental research · 2024Article
- Chronic periodontal disease is related with newly developing hypertension: a nationwide cohort study.Clinical hypertension · 2024Article
- Association of Renal Hyperfiltration with Incidence of New-Onset Diabetes Mellitus: A Nationwide Cohort Study.Journal of clinical medicine · 2024Article
- Improved Oral Health Is Associated with a Lower Risk of Late Onset Ankylosing Spondylitis: A Nationwide Cohort Study.Journal of clinical medicine · 2024Article
- Association between the triglyceride/high-density lipoprotein (TG/HDL) ratio and incidence of gout: A nationwide cohort study.Frontiers in endocrinology · 2024Article
- Association between periodontal disease status and risk of atrial fibrillation: a nationwide population-based cohort study.BMC oral health · 2023Article
- Association of Oral Health with Risk of Rheumatoid Arthritis: A Nationwide Cohort Study.Journal of personalized medicine · 2023Article
- Association between oral health behavior and chronic diseases among middle-aged and older adults in Beijing, China.BMC oral health · 2023Article
- Association of high estimated glomerular filtration rate with risk of atrial fibrillation: a nationwide cohort study.Frontiers in medicine · 2023Article
- Better oral hygiene is associated with a reduced risk of osteoporotic fracture: a nationwide cohort study.Frontiers in endocrinology · 2023Article
- Better Oral Hygiene Is Associated with a Decreased Risk of Meniere's Disease: A Nationwide Cohort Study.Journal of personalized medicine · 2022Article
- Improved Oral Health Status Is Associated with a Lower Risk of Venous Thromboembolism: A Nationwide Cohort Study.Journal of personalized medicine · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the association between oral hygiene indicators of periodontitis, tooth loss, and tooth brushing on the longitudinal fasting glucose level in non-diabetic subjects. Using a nationwide health screening database in Korea, we included non-diabetic individuals who received a health screening program with oral health check in 2009-2010. We constructed a linear mixed model for the longitudinal data of fasting glucose from the baseline to 2015. During the 4.84-year of median follow-up, 91,963 individuals (mean age 56.2 at baseline) underwent 392,780 health examinations with fasting glucose level (mmol/L). The presence of periodontitis was 39.3%. In the multivariate linear mixed analysis, periodontitis was related with increased fasting glucose levels (β = 0.0084, standard error = 0.0035, p = 0.018). Similarly, tooth loss was associated with increased level of fasting glucose (β = 0.0246, standard error = 0.0038, p < 0.001). Compared with tooth brushing ≤2 times/day, tooth brushing ≥3 times/day was associated with decreased fasting glucose levels (β = -0.0207, standard error = 0.0033, p < 0.001). Our data showed that periodontitis and tooth loss were associated with increased fasting glucose levels in non-diabetic individuals. The study findings imply that frequent tooth brushing may reduce fasting glucose levels. Further research is needed to determine the effect of periodontal intervention on glycemic control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.