Evidence map›Paper›PMID 34185327›Full record

ArticleJournal of medical virology2021

Unrecognized introduction of SARS-CoV-2 variants of concern to Central Africa: Import and local transmission of B.1.1.7 in Gabon in the very early stage of the variant spread to the African continent.

Haruka Abe, Yuri Ushijima, Rodrigue Bikangui, Samira Zoa-Assoumou, Georgelin Nguema Ondo, Gédéon Prince Manouana, Ayong More, Emilio Skarwan, Yoric Yali-Assy-Oyamli, Bénédicte Ndeboko and 5 more

Abstract read
In one paragraph

Article in Journal of medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Haruka AbeDepartment of Emerging Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Yuri UshijimaDepartment of Emerging Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Rodrigue BikanguiCentre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.
Samira Zoa-AssoumouUniversité des Sciences de la Santé, Libreville, Gabon.ORCID 0000-0002-2714-1781
Georgelin Nguema OndoCentre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.
Gédéon Prince ManouanaInstitute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
Ayong MoreCentre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.
Emilio SkarwanCentre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.
Yoric Yali-Assy-OyamliCentre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.
Bénédicte NdebokoUniversité des Sciences de la Santé, Libreville, Gabon.
Rotimi Myrabelle Avome HouechenouCentre Hospitalier Universitaire Mère-enfant Fondation Jeanne EBORI, Libreville, Gabon.
Joel Fleury Djoba SiawayaCentre Hospitalier Universitaire Mère-enfant Fondation Jeanne EBORI, Libreville, Gabon.ORCID 0000-0002-0369-0153
Bertrand LellCentre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.
Ayola Akim AdegnikaCentre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.
Jiro YasudaDepartment of Emerging Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.ORCID 0000-0001-9928-5621

Funding

Japan Agency for Medical Research and DevelopmentJapan International Cooperation Agency
6 · The paper itself

Abstract

The rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern with higher infectivity has already resulted in the enormous increase in infection cases worldwide. We report an unrecognized introduction of the variant B.1.1.7 in Gabon in December 2020, which was the initial phase of the variant introduction to Africa. The B.1.1.7 variant was also detected in a hospitalized patient in January 2021, indicating a rapid spread of the variant in Gabon since its first detection. Phylogenetic analysis revealed that the detected B.1.1.7 variants originated from the distinct regions, strongly suggesting that the B.1.1.7 variant had been repeatedly introduced to Gabon since December 2020. These results provide insights on the unrecognized risks of infections with variants of concern, and show the necessity to conduct continuous genomic monitoring for immediate alert and control of novel SARS-CoV-2 variant infections.

Indexed as

Africa, CentralCOVID-19Genome, ViralHumansMutationPhylogenyRNA, ViralSARS-CoV-2Whole Genome SequencingRNA, ViralAfricaGabonphylogenySARS-CoV-2variant

Identifiers

PMID34185327
PMCPMC8426813

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.