Evidence map›Paper›PMID 34185294›Full record

ReviewAdvances in experimental medicine and biology2020

The Many Microenvironments of Ovarian Cancer.

Hannah M Micek, Mike R Visetsouk, Andrew J Fleszar, Pamela K Kreeger

Open access · greenAbstract readReview
In one paragraph

Review in Advances in experimental medicine and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  4. Review
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  7. Microphysiological systems as models for immunologically 'cold' tumors.Frontiers in cell and developmental biology · 2024
    Review
  8. Review
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  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Hannah M Micek *Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA.
Mike R Visetsouk *Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA.
Andrew J FleszarDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA.
Pamela K KreegerDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA. kreeger@wisc.edu.
University of Wisconsin–Madison · USUniversity of Wisconsin Carbone Cancer Center · US

Funding

The role of multi-cellular aggregates vs. individual tumor cells in metastasis of high-grade serous ovarian cancerR01CA240965 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KREEGER, PAMELA K · 2020 to 2025
$2.7M
Engineered ECM platforms to analyze progression in high grade serous ovarian cancerR01CA232517 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CAMPAGNOLA, PAUL J, KREEGER, PAMELA K · 2018 to 2022
$2.4M
Soluble and mechanical factors directing mesothelial cell migration in clearance during ovarian cancer metastasisR21CA227922 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KREEGER, PAMELA K, NOTBOHM, JACOB K · 2019 to 2020
$359k
NCI NIH HHS R01 CA232517NCI NIH HHS R01 CA240965NCI NIH HHS R21 CA227922
6 · The paper itself

Abstract

High-grade serous ovarian cancer (HGSOC) is the most common and deadly subtype of ovarian cancer as it is commonly diagnosed after substantial metastasis has already occurred. The past two decades have been an active era in HGSOC research, with new information on the origin and genomic signature of the tumor cell. Additionally, studies have begun to characterize changes in the HGSOC microenvironment and examine the impact of these changes on tumor progression and response to therapies. While this knowledge may provide valuable insight into better prognosis and treatments for HGSOCs, its collection, synthesis, and application are complicated by the number of unique microenvironments in the disease-the initiating site (fallopian tube), first metastasis (ovary), distal metastases (peritoneum), and recurrent/platinum-resistant setting. Here, we review the state of our understanding of these diverse sites and highlight remaining questions.

Indexed as

Cystadenocarcinoma, SerousFallopian Tube NeoplasmsOvarian NeoplasmsCarcinoma, Ovarian EpithelialFallopian TubesFemaleHumansTumor MicroenvironmentadipocyteCAACAFcortical inclusion cystECMfallopian tubefibroblastfollicular fluidmacrophagemetastasisomentumovulationSTICTAMtranscoelomic spread

Identifiers

PMID34185294
PMCPMC8687602
OpenAlexW3174202789

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.