Evidence map›Paper›PMID 34185284›Full record

ArticleAdvances in experimental medicine and biology2020

Recent Advances in Head and Neck Tumor Microenvironment-Based Therapy.

Muzafar A Macha, Nissar A Wani, Rais A Ganai, Ajaz A Bhat, Abid Hamid, Sheema Hashem, Mohammad Haris, Sham S Chauhan, Mohammad A Zargar, Surinder K Batra

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Article in Advances in experimental medicine and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. A systematic review and network meta-analysis of therapies for locally advanced head and neck squamous cell carcinoma with different HPV status.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025
    Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Muzafar A MachaDepartment of Biotechnology, Central University of Kashmir (CUK), Ganderbal, Jammu and Kashmir, India.
Nissar A WaniDepartment of Biotechnology, Central University of Kashmir (CUK), Ganderbal, Jammu and Kashmir, India.
Rais A GanaiDepartment of Biotechnology, Central University of Kashmir (CUK), Ganderbal, Jammu and Kashmir, India.
Ajaz A BhatFunctional and Molecular Imaging Laboratory, Sidra Medicine, Doha, Qatar.
Abid HamidDepartment of Biotechnology, Central University of Kashmir (CUK), Ganderbal, Jammu and Kashmir, India.
Sheema HashemFunctional and Molecular Imaging Laboratory, Sidra Medicine, Doha, Qatar.
Mohammad HarisFunctional and Molecular Imaging Laboratory, Sidra Medicine, Doha, Qatar.
Sham S ChauhanDepartment of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Mohammad A ZargarDepartment of Biotechnology, Central University of Kashmir (CUK), Ganderbal, Jammu and Kashmir, India.
Surinder K BatraDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck squamous cell carcinomas (HNSCCs) are a group of heterogeneous aggressive tumors affecting more than half a million patients worldwide annually. While the tobacco- and alcohol-associated HNSCC tumors are declining, human papillomavirus (HPV)-induced tumors are on rise. Despite recent advances in multimodality therapeutic interventions including surgery in combination with chemoradiation therapy (CRT), the overall 5-year survival has not improved more than 50%. The underlying reasons for this dismal prognosis is the intrinsic or acquired resistance to CRT. While previous studies were focused to target tumor cells, recent findings have implicated the involvement of tumor microenvironment (TME) on tumor progression and response to therapy. HNSCC TME includes cancer-associated fibroblasts (CAFs), endothelial cells, immune cells, endocrine cells, and the extracellular matrix (ECM) proteins including collagen and fibronectin. Understanding the crosstalk between TME and cancer cells is important to formulate more effective novel therapies and to overcome resistance mechanisms. Here, we summarized the current literature on recent advances on HNSCC TME with special emphasis on novel cell-cell interactions and therapies currently under development.

Indexed as

Head and Neck NeoplasmsPapillomavirus InfectionsEndothelial CellsHumansPapillomaviridaeSquamous Cell Carcinoma of Head and NeckTumor MicroenvironmentCancer-associated fibroblastsChemo-Radiation TherapyDisease Free SurvivalExtracellular matrixGenetically Engineered Mouse ModelsHead and Neck Squamous Cell CarcinomaImmune infiltrationMyeloid-Derived Suppressor CellsOral Squamous Cell CarcinomaOverall survivalTargeted TherapyTumor Microenvironment

Identifiers

PMID34185284

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.