Evidence map›Paper›PMID 34185266›Full record

ReviewCurrent osteoporosis reports2021

Finite Element Analysis of Fracture Fixation.

Gregory S Lewis, Dominic Mischler, Hwabok Wee, J Spence Reid, Peter Varga

Abstract readReview
In one paragraph

Review in Current osteoporosis reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  9. Finite element andFrontiers in bioengineering and biotechnology · 2026
    Article
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  14. Review
  15. Article
  16. Effects of Plate-Bone Contact on Bridge Plate Fracture Fixation Biomechanics: Computational, Experimental, and Analytical Modeling.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gregory S LewisDepartment of Orthopaedics and Rehabilitation, Pennsylvania State University, Hershey, PA, USA. greglewis@psu.edu.ORCID 0000-0002-3673-0182
Dominic MischlerAO Research Institute Davos, Davos, Switzerland.ORCID 0000-0002-9583-2381
Hwabok WeeDepartment of Orthopaedics and Rehabilitation, Pennsylvania State University, Hershey, PA, USA.ORCID 0000-0002-2875-4803
J Spence ReidDepartment of Orthopaedics and Rehabilitation, Pennsylvania State University, Hershey, PA, USA.
Peter VargaAO Research Institute Davos, Davos, Switzerland.ORCID 0000-0003-2738-6436

Funding

Fracture Fixation Biomechanics Simulator with Adaptive Virtual CoachingR01EB029207 · NIBIB · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LEWIS, GREGORY STEPHEN, REID , JOHN SPENCE · 2020 to 2023
$1.2M
AO Foundation AR 2018/01NIBIB NIH HHS 1R01EB029207-01NIBIB NIH HHS R01 EB029207
6 · The paper itself

Abstract

purpose of reviewFracture fixation aims to provide stability and promote healing, but remains challenging in unstable and osteoporotic fractures with increased risk of construct failure and nonunion. The first part of this article reviews the clinical motivation behind finite element analysis of fracture fixation, its strengths and weaknesses, how models are developed and validated, and how outputs are typically interpreted. The second part reviews recent modeling studies of the femur and proximal humerus, areas with particular relevance to fragility fractures. RECENT

findingsThere is some consensus in the literature around how certain modeling aspects are pragmatically formulated, including bone and implant geometries, meshing, material properties, interactions, and loads and boundary conditions. Studies most often focus on predicted implant stress, bone strain surrounding screws, or interfragmentary displacements. However, most models are not rigorously validated. With refined modeling methods, improved validation efforts, and large-scale systematic analyses, finite element analysis is poised to advance the understanding of fracture fixation failure, enable optimization of implant designs, and improve surgical guidance.

Indexed as

Finite Element AnalysisFemaleFemoral FracturesFracture FixationHumansHumeral FracturesOsteoporotic FracturesBiomechanicsFinite element analysisFracture fixationNailPlateScrew

Identifiers

PMID34185266
PMCPMC8422380

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.