ArticleMolecular biotechnology2021
Discovery of α-Glucosidase Inhibitors from Marine Microorganisms: Optimization of Culture Conditions and Medium Composition.
Article in Molecular biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Functional and Organic Foods in Enhancing the Oral and Dental Health and Hygiene-A Comprehensive Review.Food science & nutrition · 2026Review
- Synthesis, α-Glucosidase, α-Amylase, and Aldol Reductase Inhibitory Activity with Molecular Docking Study of Novel Imidazo[1,2-ACS omega · 2024Article
- An Update on Dipeptidyl Peptidase-IV Inhibiting Peptides.Current protein & peptide science · 2024Review
- Enzyme Inhibitors from Gorgonians and Soft Corals.Marine drugs · 2023Review
- Responsive Fluorescent Coumarin-Cinnamic Acid Conjugates for α-Glucosidase Detection.Frontiers in chemistry · 2022Article
- β-galactosidase GALA fromBioengineered · 2021Article
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
Various studies showed that the suppression of α-glucosidase activity can impede the glucose absorption in our body, and therefore, it can be used to treat type 2 diabetes. Hence, the compounds with anti-α-glucosidase have gained considerable attention because of their potential application in diabetes treatment. In previous literature studies, these anti-α-glucosidase compounds were extracted from plants and fungus. Less studies are being conducted to identify the anti-α-glucosidase compounds in the microbial community. In this study, 23 marine bacterial strains were screened for their potential to suppress the α-glucosidase activity. The highest inhibitory activity was exhibited by isolated L06 which was identified as Oceanimonas smirnovii EBL6. The cultivation conditions, such as temperature and pH, were optimized to increase the production of α-glucosidase inhibitors by Oceanimonas smirnovii EBL6 strain. The result findings showed that the highest yield of α-glucosidase inhibitors can be obtained at the culture time of 120 h, fermentation temperature of 30 °C, and pH 4.6. Under these conditions, the inhibitory activity of α-glucosidase can reach 81%. The IC
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