Evidence map›Paper›PMID 34185217›Full record

ArticleWiener medizinische Wochenschrift (1946)2022

Histopathological progression of hidradenitis suppurativa/acne inversa : A morphological study with a closer look on the early changes of the folliculosebaceous apocrine apparatus.

Elena Castelli, Elisabetta Orlando, Rossana Porcasi, Giovanna Tilotta, Guiseppe Pistone, Maria Rita Bongiorno, Uwe Wollina

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In one paragraph

Article in Wiener medizinische Wochenschrift (1946), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Elena CastelliDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), UOC of Dermatology, University of Palermo, AOUP Paolo Giaccone, Via del Vespro 131, 90127, Palermo, PA, Italy. elena.castelli@unipa.it.
Elisabetta OrlandoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), UOC of Pathology, University of Palermo, AOUP Paolo Giaccone, Palermo, PA, Italy.
Rossana PorcasiDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), UOC of Pathology, University of Palermo, AOUP Paolo Giaccone, Palermo, PA, Italy.
Giovanna TilottaDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), UOC of Dermatology, University of Palermo, AOUP Paolo Giaccone, Via del Vespro 131, 90127, Palermo, PA, Italy.
Guiseppe PistoneDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), UOC of Dermatology, University of Palermo, AOUP Paolo Giaccone, Via del Vespro 131, 90127, Palermo, PA, Italy.
Maria Rita BongiornoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), UOC of Dermatology, University of Palermo, AOUP Paolo Giaccone, Via del Vespro 131, 90127, Palermo, PA, Italy.
Uwe WollinaDepartment of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital, Dresden, Germany.ORCID http://orcid.org/0000-0001-5933-2913
University of Palermo · ITDepartment of Health · ESStädtisches Klinikum Dresden · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is generally acknowledged that the first morphological change of hidradenitis suppurativa/acne inversa (HS/AI) consists of infundibular plugging of the folliculosebaceous apocrine apparatus, which is followed by acute and chronic inflammation, cysts with sinus formation, and fibrosis. Alternatively, it has been hypothesized that HS/AI is primarily a neutrophilic autoinflammatory disease and that the follicular plugging typical of this disease is secondary to inflammation.

objectiveTo review the sequence of the changes that mark the disease development, we have performed a histopathologic study on the surgical material from a series of axillary and inguinal/perineal cases.

methodsThe histologic material from surgery on Hurley's second and third stage HS/AI was retrieved and collected with the patients' clinical images. The virtually uninvolved skin peripheral to the lesions was studied together with the main inflammatory foci on vertical sections stained with hematoxylin-eosin and immunohistochemistry for the follicle sheaths.

resultsThe fully developed lesions showed acute and chronic, suppurative and granulomatous inflammation overlapping fibrosis, cysts, and sinuses. Instead, the skin adjacent to florid inflammation showed plugging and dysmorphic alterations of the hair follicles associated with immunopathological changes of the inner root sheath keratin expression.

conclusionOur observations coincide with the classical pathological studies on the progressive changes of HS/AI; however, in our specimens, the virtually normal skin peripheral to the fully developed lesions show seemingly initial follicular changes that suggest development error. This finding would support the hypothesis of combined mutation-induced epithelial differentiative defects and immunological derangement in HS/AI pathogenesis.

Indexed as

Hidradenitis SuppurativaHair FollicleHumansImmunohistochemistryInflammationSkinAutoinflammationDevelopmental disturbancesEarly lesionsMutationsUninvolved skin

Identifiers

PMID34185217
OpenAlexW3175940466

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.