Evidence map›Paper›PMID 34185168›Full record

ReviewLasers in medical science2021

An improved in vitro photochemical internalization protocol for 3D spheroid cultures.

Lina Nguyen, Steen J Madsen, Kristian Berg, Henry Hirschberg

Abstract readReview
PubMed Publisher
In one paragraph

Review in Lasers in medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 63% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Lina NguyenBeckman Laser Institute and Medical Clinic, University of California, Irvine 1002 Health Sciences Rd, Irvine, CA, USA. Linanguyen824@gmail.com.
Steen J MadsenDepartment of Health Physics and Diagnostic Sciences, University of Nevada, Las Vegas, NV, USA.
Kristian BergDepartment of Radiation Biology, Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway.
Henry HirschbergBeckman Laser Institute and Medical Clinic, University of California, Irvine 1002 Health Sciences Rd, Irvine, CA, USA.
Beckman Laser Institute and Medical Clinic · USNorwegian Cancer Society · NOUniversity of Nevada, Las Vegas · US

Funding

The Norwegian Radium Hospital Research Foundation 1305 AND 1503
6 · The paper itself

Abstract

Photochemical internalization (PCI) is a modified form of photodynamic therapy (PDT) that enhances the efficacy of therapeutic agents in a site and temporal specific manner in both in vitro and in vivo publications. The purpose of the study reported here was to evaluate the benefits of a modified PCI protocol in a 3D rat glioma spheroid model. In the modified protocol, F98 glioma cells were incubated with photosensitizer (AlPcS

Indexed as

GliomaPhotochemotherapyAnimalsBleomycinCell Line, TumorPhotosensitizing AgentsRatsBleomycinPhotosensitizing AgentsDrug activationPhotochemical internalizationPhotodynamic therapyTumor spheroids

Identifiers

PMID34185168
OpenAlexW3173440705

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.