ReviewTransboundary and emerging diseases2021
Porcine circovirus 3 (PCV-3) as a causal agent of disease in swine and a proposal of PCV-3 associated disease case definition.
Review in Transboundary and emerging diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Porcine circovirus 4 status of domestic pigs and wild animals in Poland.Journal of veterinary research · 2026Article
- Beyond labels: current sequencing data do not support standardized porcine circovirus 3 (PCV3) genotypes.BMC veterinary research · 2026Article
- Concurrent histological lesions and molecular detection of porcine circovirus 3 in pigs with skeletal abnormalities and humpy-back posture.Veterinary pathology · 2026Article
- Detection of PCV3 in various sample types from wild boars in Poland.BMC veterinary research · 2026Article
- Emerging Challenges and Advances in Porcine Circovirus: A Decade in Review.Transboundary and emerging diseases · 2026Review
- Development of a Highly Specific Monoclonal Antibody-Based Sandwich ELISA for Rapid Detection of Porcine Circovirus Type 3.Viruses · 2025Article
- Review
- Molecular epidemiology and genetic characterization of PCV2 and PCV3 circulating in domestic pigs and wild boars in central-southern regions of Italy.BMC veterinary research · 2025Article
- Longitudinal Monitoring of Mono- and Coinfections Involving Primary Porcine Reproductive Viruses (PCV2, PPV1, and PRRSV) as Well as Emerging Viruses (PCV3, PCV4, and nPPVs) in Primiparous and Multiparous Sows and Their Litters.Pathogens (Basel, Switzerland) · 2025Article
- Evaluation of IgM, IgA, and IgG Antibody Responses Against PCV3 and PCV2 in Tissues of Aborted Fetuses from Late-Term Co-Infected Sows.Pathogens (Basel, Switzerland) · 2025Article
- Investigating the Presence and Genetic Variability of Porcine Circovirus Types 2 and 3 in Live Markets in Border Cities of Northeast China.Transboundary and emerging diseases · 2025Article
- Dynamics of Porcine Circovirus Type 3 Detection in Pre-Weaning Piglets: Insight From Multiple Sampling Methods.Transboundary and emerging diseases · 2025Article
- Retrospective Study Reveals Decades of PCV4 Circulation in Spain.Transboundary and emerging diseases · 2025Article
- Dynamics of PCV2 and PCV3 in the Serum and Oral Fluids of Pigs After PCV2 Vaccination in a Commercial Farm.Vaccines · 2024Article
- A case report of porcine circovirus 3 (PCV3) reproductive disease in Iberian semi-outdoor reared sows.Porcine health management · 2024Article
- Retrospective investigation of porcine circoviruses in cases of porcine dermatitis and nephropathy syndrome.Veterinary research · 2024Article
- Article
- Main Causes of Death in Piglets from Different Brazilian Nursery Farms Based on Clinical, Microbiological, and Pathological Aspects.Animals : an open access journal from MDPI · 2023Article
- Detection of Porcine Circovirus Type 3 in Serum, Semen, Oral Fluid, and Preputial Fluid Samples of Boars.Veterinary sciences · 2023Article
- A Retrospective Analysis of Porcine Circovirus Type 3 in Samples Collected from 2008 to 2021 in Mexico.Viruses · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porcine circovirus 3 (PCV-3) was discovered in 2015 using next-generation sequencing (NGS) methods. Since then, the virus has been detected worldwide in pigs displaying several clinical-pathological outcomes as well as in healthy animals. The objective of this review is to critically discuss the evidence existing so far regarding PCV-3 as a swine pathogen. In fact, a significant number of publications claim PCV-3 as a disease causal infectious agent, but very few of them have shown strong evidence of such potential causality. The most convincing proofs of disease association are those that demonstrate a clinical picture linked to multisystemic lymphoplasmacytic to lymphohistiocytic perivascular inflammation and presence of viral nucleic acid within these lesions. Based on these evidence, individual case definitions for PCV-3-reproductive disease and PCV-3-systemic disease are proposed to standardize diagnostic criteria for PCV-3-associated diseases. However, the real frequency of these clinical-pathological conditions linked to the novel virus is unknown, and the most frequent outcome of PCV-3 infection is likely subclinical based on its worlwide distribution.
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