ArticleHuman brain mapping2021
R2* and quantitative susceptibility mapping in deep gray matter of 498 healthy controls from 5 to 90 years.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Quantitative susceptibility mapping in pediatric neuroimaging: a systematic review of applications and advancements.Pediatric radiology · 2026Pooled it
- Revisiting brain iron deficiency in restless legs syndrome using magnetic resonance imaging.NeuroImage. Clinical · 2022Pooled it
- Does quantitative susceptibility mapping elucidate age-related alterations in deep gray matter iron deposition? A systematic review.Radiological physics and technology · 2026Review
- Automated Surface-Based Segmentation of Deep Gray Matter Regions Based on Diffusion Tensor Images Reveals Unique Age Trajectories Over the Healthy Lifespan.NMR in biomedicine · 2026Article
- Susceptibility Source Separation Unveils Paramagnetic and Diamagnetic Trajectories in Healthy Brains From 5 to 90 Years.NMR in biomedicine · 2026Article
- Regulation of brain iron homeostasis and its influence on cognitive function.European radiology · 2026Article
- Assessing Age-Associated Influences on Paramagnetic and Diamagnetic Susceptibility Maps in Postmortem Human Brains.NMR in biomedicine · 2026Article
- Voxel-Wise Whole-Brain Analysis in Quantitative Susceptibility Mapping: A Narrative Review.Human brain mapping · 2026Review
- Excess iron in deep gray matter is associated with cognitive and functional decline: The mediating role of white matter myelin.NeuroImage · 2026Article
- Repeatability of Susceptibility Source Separation Methods in Human Brain: A Single-Site Study at 3 T.NMR in biomedicine · 2026Article
- Ultrashort Echo Time Quantitative Susceptibility Source Separation in Musculoskeletal System: A Feasibility Study.Journal of imaging · 2026Article
- Mapping heterogeneous region- and tissue-specific brain ageing patterns using quantitative MRI.Brain communications · 2026Article
- Using QSM to investigate the iron deposition patterns in deep gray matter nuclei during the aging process in healthy populations.Frontiers in aging neuroscience · 2026Article
- Importance of RMagnetic resonance in medicine · 2026Article
- Effects of Motion in Ultrashort Echo Time Quantitative Susceptibility Mapping for Musculoskeletal Imaging.Journal of imaging · 2025Article
- Quantitative Susceptibility Mapping of Deep Grey Matter in MS: Association With Clinical Scores and Brain Volume Measures.Brain and behavior · 2025Article
- Imaging Developmental Trajectories of Laminar Magnetic Susceptibility Throughout Adulthood in Human Brain Cortex.Human brain mapping · 2025Article
- Improving quantitative susceptibility mapping for the identification of traumatic brain injury neurodegeneration at the individual level.Zeitschrift fur medizinische Physik · 2025Article
- Paramagnetic susceptibility mapping better quantifies brain iron content in Parkinson's disease with RBD.NPJ Parkinson's disease · 2025Article
- Iron Deficiency Without Anemia and Reduced Basal Ganglia Iron Content in Youths.JAMA network open · 2025Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Putative MRI markers of iron in deep gray matter have demonstrated age related changes during discrete periods of healthy childhood or adulthood, but few studies have included subjects across the lifespan. This study reports both transverse relaxation rate (R2*) and quantitative susceptibility mapping (QSM) of four primary deep gray matter regions (thalamus, putamen, caudate, and globus pallidus) in 498 healthy individuals aged 5-90 years. In the caudate, putamen, and globus pallidus, increases of QSM and R2* were steepest during childhood continuing gradually throughout adulthood, except caudate susceptibility which reached a plateau in the late 30s. The thalamus had a unique profile with steeper changes of R2* (reflecting additive effects of myelin and iron) than QSM during childhood, both reaching a plateau in the mid-30s to early 40s and decreasing thereafter. There were no hemispheric or sex differences for any region. Notably, both R2* and QSM values showed more inter-subject variability with increasing age from 5 to 90 years, potentially reflecting a common starting point in iron/myelination during childhood that diverges as a result of lifestyle and genetic factors that accumulate with age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.