Evidence map›Paper›PMID 34184765›Full record

ArticleThe EMBO journal2021

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Kensuke Ninomiya, Junichi Iwakiri, Mahmoud Khamis Aly, Yuriko Sakaguchi, Shungo Adachi, Tohru Natsume, Goro Terai, Kiyoshi Asai, Tsutomu Suzuki, Tetsuro Hirose

Open access · greenAbstract read
In one paragraph

Article in The EMBO journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Subcellular localization as a driver of protein function.Nature reviews. Molecular cell biology · 2026
    Review
  5. Nuclear mNature chemical biology · 2026
    Article
  6. Article
  7. Heat meets repeat, easing the inflammatory beat.Science China. Life sciences · 2026
    Article
  8. Article
  9. Review
  10. Downregulation of Gene Expression by Alpha Satellite Transcripts.International journal of molecular sciences · 2025
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Methyladenine as a regulator of biomolecular condensation.Frontiers in molecular biosciences · 2025
    Review
  17. Article
  18. CLK2 Condensates Reorganize Nuclear Speckles and Induce Intron Retention.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  19. Review
  20. YTHDC1 mThe EMBO journal · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Kensuke NinomiyaGraduate School of Frontier Biosciences, Osaka University, Suita, Japan.
Junichi IwakiriGraduate School of Frontier Sciences, University of Tokyo, Kashiwa, Japan.
Mahmoud Khamis AlyInstitute for Genetic Medicine, Hokkaido University, Sapporo, Japan.
Yuriko SakaguchiGraduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Shungo AdachiCellular and Molecular Biotechnology Research Institute, National Institute for Advanced Industrial Science and Technology (AIST), Tokyo, Japan.
Tohru NatsumeCellular and Molecular Biotechnology Research Institute, National Institute for Advanced Industrial Science and Technology (AIST), Tokyo, Japan.
Goro TeraiGraduate School of Frontier Sciences, University of Tokyo, Kashiwa, Japan.
Kiyoshi AsaiGraduate School of Frontier Sciences, University of Tokyo, Kashiwa, Japan.
Tsutomu SuzukiGraduate School of Engineering, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-9731-1731
Tetsuro HiroseGraduate School of Frontier Biosciences, Osaka University, Suita, Japan.ORCID 0000-0003-1068-5464
The University of Tokyo · JPHokkaido University · JPNational Institute of Advanced Industrial Science and Technology · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nuclear stress bodies (nSBs) are nuclear membraneless organelles formed around stress-inducible HSATIII architectural long noncoding RNAs (lncRNAs). nSBs repress splicing of hundreds of introns during thermal stress recovery, which are partly regulated by CLK1 kinase phosphorylation of temperature-dependent Ser/Arg-rich splicing factors (SRSFs). Here, we report a distinct mechanism for this splicing repression through protein sequestration by nSBs. Comprehensive identification of RNA-binding proteins revealed HSATIII association with proteins related to N

Indexed as

RNA SplicingAdenosineCell NucleusHeLa CellsHumansNerve Tissue ProteinsPhosphorylationProtein Serine-Threonine KinasesProtein-Tyrosine KinasesRepetitive Sequences, Nucleic AcidRNA, Long NoncodingRNA, MessengerRNA Splicing FactorsSerine-Arginine Splicing FactorsTemperatureAdenosineClk dual-specificity kinasesNerve Tissue ProteinsN-methyladenosineProtein Serine-Threonine KinasesProtein-Tyrosine KinasesRNA, Long NoncodingRNA, MessengerRNA Splicing FactorsSerine-Arginine Splicing FactorsSRSF9 protein, humanYTHDC1 protein, humanlong noncoding RNAm6A modificationmolecular spongenuclear stress bodiespre-mRNA splicing

Identifiers

PMID34184765
PMCPMC8327944
OpenAlexW3174745518

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.