Evidence map›Paper›PMID 34184558›Full record

ArticleAutism : the international journal of research and practice2022

Medical symptoms and conditions in autistic women.

Tslil Simantov, Alexa Pohl, Alexandros Tsompanidis, Elizabeth Weir, Michael V Lombardo, Amber Ruigrok, Paula Smith, Carrie Allison, Simon Baron-Cohen, Florina Uzefovsky

Open access · hybridAbstract read
In one paragraph

Article in Autism : the international journal of research and practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Tslil SimantovBen-Gurion University of the Negev, Israel.ORCID 0000-0002-6562-6288
Alexa PohlUniversity of Cambridge, UK.
Alexandros TsompanidisUniversity of Cambridge, UK.
Elizabeth WeirUniversity of Cambridge, UK.
Michael V LombardoUniversity of Cambridge, UK.
Amber RuigrokUniversity of Cambridge, UK.
Paula SmithUniversity of Cambridge, UK.
Carrie AllisonUniversity of Cambridge, UK.ORCID 0000-0003-2272-2090
Simon Baron-CohenUniversity of Cambridge, UK.
Florina UzefovskyBen-Gurion University of the Negev, Israel.ORCID 0000-0003-4571-2514
University of Cambridge · GBBen-Gurion University of the Negev · IL

Funding

Department of HealthWellcome Trust
6 · The paper itself

Abstract

lay abstractSex-steroids, such as testosterone, are thought to be one of the biological factors implicated in autism. This relies on the sex bias in the diagnosis of autism (boys are approximately four times more likely to be diagnosed than girls) and findings of associations with fetal testosterone levels in traits and abilities related to autism. The current study aimed to examine the association between medical conditions and physical symptoms, which tend to manifest in adulthood, and autism in females. Moreover, we examined their association with autistic traits throughout the spectrum. We focused on autistic women because there is little research focusing on the healthcare needs of autistic women, but those that exist suggest heightened vulnerability, and lower access to medical care. We find that conditions related to steroid hormones function are more frequent in autistic women and that they correlate with autistic traits. Specifically, we found that body mass index, reproductive system diagnoses, prediabetes symptoms, irregular puberty onset, and menstrual irregularities were significantly more frequent in autistic women and were significantly correlated with autistic traits in neurotypical women. The findings have important implications for raising awareness in autistic women of the possibility of medical conditions which might need medical attention. In addition, healthcare providers should consider these associations when performing healthcare maintenance checks and/or screening for autism.

Indexed as

Autism Spectrum DisorderAutistic DisorderAdultBody Mass IndexFemaleHumansMalePhenotypeautismclinicalfemalespubertysteroidstestosterone

Identifiers

PMID34184558
PMCPMC8814970
OpenAlexW3174812215

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.