ArticleEnvironmental science and pollution research international2021
Pharmacophore based in silico study with laboratory verification-environmental explanation of prostate cancer recurrence.
Article in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Hyperthermia intravesical chemotherapy acts as a promising alternative to bacillus Calmette-Guérin instillation in non-muscle-invasive bladder cancer: a network meta-analysis.Frontiers in oncology · 2023Pooled it
- Research advances on the risk of prostate cancer from phthalates exposure: from epidemiological evidence to multidimensional prevention and control.Frontiers in cell and developmental biology · 2025Review
- Article
- Effects of Dibutylphthalate and Steroid Hormone Mixture on Human Prostate Cells.International journal of molecular sciences · 2023Article
- TACE responser NDRG1 acts as a guardian against ferroptosis to drive tumorgenesis and metastasis in HCC.Biological procedures online · 2023Article
- Development and Validation of the Promising PPAR Signaling Pathway-Based Prognostic Prediction Model in Uterine Cervical Cancer.PPAR research · 2023Article
- Bibliometric analysis of the association between drinking water pollution and bladder cancer.Frontiers in oncology · 2023Article
- Differences in the pathogenetic characteristics of prostate cancer in the transitional and peripheral zones and the possible molecular biological mechanisms.Frontiers in oncology · 2023Review
- The Comprehensive Analysis Illustrates the Role of CDCA5 in Breast Cancer: An Effective Diagnosis and Prognosis Biomarker.International journal of genomics · 2023Article
- The Identification of Immune-Related Biomarkers for Osteoarthritis Immunotherapy Based on Single-Cell RNA Sequencing Analysis.Genetics research · 2023Article
- Immunotherapy and Immune Infiltration in Patients with Clear Cell Renal Cell Carcinoma: A Comprehensive Analysis.Genetics research · 2023Article
- Single-cell RNA sequencing and traditional RNA sequencing reveals the role of cancer-associated fibroblasts in oral squamous cell carcinoma cohort.Frontiers in oncology · 2023Article
- Endocrine Disruptors and Prostate Cancer.International journal of molecular sciences · 2022Review
- Identification of the Immune Cell Infiltration Landscape in Head and Neck Squamous Cell Carcinoma (HNSC) for the Exploration of Immunotherapy and Prognosis.Genetics research · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The prediction of harmful effects can guide research on the health hazards of environmental pollutants. The development of a computer-aided drug design in pharmacological technology and omics database remarkably facilitates the prediction of the possible harmful effects of hazardous substances. In this study, the pharmacophore target database based on molecular structure served as a bridge between pollutants and genes and combined with the omics database and molecular pathway enrichment technology to predict the potential prostatic cancer-promoting effect of dibutyl phthalate. Cell experiments and gene expression were carried out to verify the previous prediction, and the characteristics of harmful effects were further explored. Low concentrations of dibutyl phthalate may have androgen-independent prostate cancer-promoting effects, which may put patients receiving androgen deprivation therapy in danger. This study suggests the potential negative effects of phthalates on prostate cancer and a method for predicting harmful effects on the basis of pharmacology technology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.