Evidence map›Paper›PMID 34184202›Full record

Trial reportInternational urology and nephrology2022

Seven months of aerobic intradialytic exercise training can prevent muscle loss in haemodialysis patients: an ultrasonography study.

Argyro A Krase, Gerasimos Terzis, Christoforos D Giannaki, Aggeliki N Stasinaki, Thomas J Wilkinson, Alice C Smith, Constantinos Zorz, Chrisitna Karatzaferi, Ioannis Stefanidis, Giorgos K Sakkas

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International urology and nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 6 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03905551 nacompletednot on this map

The Effect of Exercise Rehabilitation Regimes in Combination With Changes in Dialysis Procedures in Aspects Related to Quality of Life and Health in End Stage Renal Disease Patients

TypeinterventionalSponsorUniversity of ThessalyRan2015 to 2020Enrolled72ConditionsEnd Stage Renal Failure on DialysisArmsCold Dialysis, Typical Dialysis, Exercise
NCT07151742 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Investigation of the Effects of Intradialytic Combined Exercises on Dialysis Parameters and Muscle Oxygenation in Sarcopenic Hemodialysis Patients

TypeinterventionalSponsorIstinye UniversityRan2025 to 2025Enrolled40ConditionsChronic Kidney Disease, Stage 5, SarcopeniaArmsEXERCISE TRAINING WITH OR WITHOUT MEDICATION
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 6 syntheses or guidelines pooled it, 25 citations in OpenAlex.

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  4. Interventions for fatigue in people with kidney failure requiring dialysis.The Cochrane database of systematic reviews · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Argyro A KraseDepartment of Physical Education and Sport Science, University of Thessaly, 42100, Trikala, Greece.
Gerasimos TerzisSports Performance Laboratory, School of Physical Education and Sport Science, National and Kapodistrian University of Athens, Athens, Greece.
Christoforos D GiannakiDepartment of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus.
Aggeliki N StasinakiSports Performance Laboratory, School of Physical Education and Sport Science, National and Kapodistrian University of Athens, Athens, Greece.
Thomas J WilkinsonDepartment of Health Sciences, University of Leicester, Leicester, UK.
Alice C SmithDepartment of Health Sciences, University of Leicester, Leicester, UK.
Constantinos ZorzDivision of Nephrology, Department of Medicine, University of Thessaly, Larissa, Greece.
Chrisitna KaratzaferiDepartment of Physical Education and Sport Science, University of Thessaly, 42100, Trikala, Greece.
Ioannis StefanidisDivision of Nephrology, Department of Medicine, University of Thessaly, Larissa, Greece.
Giorgos K SakkasDepartment of Physical Education and Sport Science, University of Thessaly, 42100, Trikala, Greece. gsakkas@uth.gr.ORCID http://orcid.org/0000-0002-2462-995X
University of Thessaly · GRNational and Kapodistrian University of Athens · GRUniversity of Leicester · GBUniversity of Nicosia · CY

Funding

H2020 Marie Skłodowska-Curie Actions 645648
6 · The paper itself

Abstract

purposeThis study aimed to evaluate the effects of 7-month intradialytic exercise training (IDE) on vastus lateralis (VL) muscle architecture, functional capacity and quality of life in stable haemodialysis (HD) patients.

methods44 HD patients were randomly assigned into an Exercise Group (EG = 21), which they received 7 months of IET, at 60% of pre-assessed maximum aerobic power, 3/week) or into a Control Group (CG = 23, no exercise). VL architecture was evaluated with ultrasonography, functional capacity was assessed using a series of functional tests (6 min walking test, 5 repetitions sit-to-stand, sit-to-stand 60 s, handgrip strength), and maximal aerobic power determined with a modified version of the Åstrand test. Quality of life and fatigue levels were evaluated using validated questionnaires.

resultsVL fascicle angle and length did not change significantly in both groups (P > 0.05). Muscle thickness decreased in CG (P = 0.02) while it was fully preserved in the EG. Functional capacity increased only in the EG (6 min walking test 15.79 ± 12.35%, P < 0.001; max aerobic power 26.36 ± 1.24%, P < 0.001; STS-60rep: 10.23 ± 1.60%, P < 0.000; hand grip strength: 5.14 ± 28.30%, P < 0.02).

conclusionIntradialytic aerobic exercise training, improves functional capacity and prevents thigh muscle mass loss in HD patients. It is evident that muscle ultrasonography could play a pivotal role in assessing muscle quality changes in haemodialysis patients. A higher level of training intensity or combination with resistance exercises may be required to further improve anabolism and influence muscle architecture in this patient population. CLINICAL TRIAL REGISTRY NUMBER: NCT03905551.

Indexed as

Exercise TherapyRenal DialysisAgedAged, 80 and overExerciseFemaleHumansMaleMiddle AgedQuadriceps MuscleTime FactorsUltrasonographyEnd-stage renal diseaseIntradialytic exerciseMuscle atrophySkeletal muscle architecture

Identifiers

PMID34184202
OpenAlexW3176563147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.