Evidence map›Paper›PMID 34184200›Full record

ArticleMolecular biology reports2021

CCR3 gene overexpression in patients with Down syndrome.

Michele Salemi, Rossella Cannarella, Giovanna Marchese, Maria Grazia Salluzzo, Maria Ravo, Concetta Barone, Angela Cordella, Salvatore Caniglia, Roberto Castiglione, Alda Ragalmuto and 2 more

Abstract read
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Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Michele Salemi *Oasi Research Institute-IRCCS, Troina, EN, Italy. micezia@tiscali.it.ORCID http://orcid.org/0000-0003-1075-8993
Rossella Cannarella *Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Giovanna MarcheseGenomix4Life Srl, Baronissi, SA, Italy.
Maria Grazia SalluzzoOasi Research Institute-IRCCS, Troina, EN, Italy.
Maria RavoGenomix4Life Srl, Baronissi, SA, Italy.
Concetta BaroneOasi Research Institute-IRCCS, Troina, EN, Italy.
Angela CordellaGenomix4Life Srl, Baronissi, SA, Italy.
Salvatore CanigliaOasi Research Institute-IRCCS, Troina, EN, Italy.
Roberto CastiglioneDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Alda RagalmutoOasi Research Institute-IRCCS, Troina, EN, Italy.
Aldo E CalogeroDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Corrado RomanoOasi Research Institute-IRCCS, Troina, EN, Italy.
Oasi Maria SS · ITUniversity of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chromosome 21 trisomy or Down syndrome (DS) is the most common genetic cause of intellectual disability (ID). DS is also associated with hypotonia, muscle weakness, autoimmune diseases, and congenital heart disease. C-C chemokine receptor type 3 (CCR3) plays a role in inflammatory, autoimmune, and neuronal migration mechanisms. The present study aimed to evaluate the expression of the CCR3 gene by NGS and qRT-PCR in patients with DS and normal controls (NC). The CCR3 gene was over-expressed in DS patients compared to NC. These data suggest that an over-expression of the CCR3 gene is associated with the phenotype of patients with DS.

Indexed as

AdultDown SyndromeFemaleGene ExpressionHumansIntellectual DisabilityMaleMiddle AgedPhenotypeReceptors, CCR3TranscriptomeTrisomyCCR3 protein, humanReceptors, CCR3CCR3Down syndromeIntellectual disabilityNGSqRT-PCR

Identifiers

PMID34184200
OpenAlexW3173812614

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.