Evidence map›Paper›PMID 34184175›Full record

ArticleNeurocritical care2021

Electrocerebral Signature of Cardiac Death.

Adu L Matory, Ayham Alkhachroum, Wei-Ting Chiu, Andrey Eliseyev, Kevin Doyle, Benjamin Rohaut, Jennifer A Egbebike, Angela G Velazquez, Caroline Der-Nigoghossian, Lucy Paniker and 5 more

Open access · greenAbstract read
In one paragraph

Article in Neurocritical care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Diagnostic test accuracy for cessation of circulation during death determination: a systematic review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
    Pooled it
  2. Brain-based arterial pulse pressure threshold for death determination: a systematic review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
    Pooled it
  3. Review
  4. Observational
  5. Review
  6. Knowledge gaps in heart and lung donation after the circulatory determination of death: Report of a workshop of the National Heart, Lung, and Blood Institute.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024
    Article
  7. Article
  8. Review
  9. Reduced Heartbeat-Evoked Responses in a Near-Death Case Report.Journal of clinical neurology (Seoul, Korea) · 2023
    Article
  10. Review
  11. Review
  12. Between life and death: the brain twilight zones.Frontiers in neuroscience · 2023
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 4 countries.

Adu L MatoryDepartment of Neurology, Neurological Institute, Columbia University Medical Center, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York, NY, 10032, USA.
Ayham AlkhachroumDepartment of Neurology, Neurological Institute, Columbia University Medical Center, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York, NY, 10032, USA.
Wei-Ting ChiuDepartment of Neurology, Neurological Institute, Columbia University Medical Center, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York, NY, 10032, USA.
Andrey EliseyevDepartment of Neurology, Neurological Institute, Columbia University Medical Center, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York, NY, 10032, USA.
Kevin DoyleDepartment of Neurology, Neurological Institute, Columbia University Medical Center, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York, NY, 10032, USA.
Benjamin RohautDepartment of Neurology, Neurological Institute, Columbia University Medical Center, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York, NY, 10032, USA.
Jennifer A EgbebikeDepartment of Neurology, Neurological Institute, Columbia University Medical Center, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York, NY, 10032, USA.
Angela G VelazquezDepartment of Neurology, Neurological Institute, Columbia University Medical Center, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York, NY, 10032, USA.
Caroline Der-NigoghossianPharmacy, Columbia University Irving Medical Center, New York, NY, USA.
Lucy PanikerDepartment of Neurology, Neurological Institute, Columbia University Medical Center, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York, NY, 10032, USA.
Kenneth M PragerClinical Ethics, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Sachin AgarwalDepartment of Neurology, Neurological Institute, Columbia University Medical Center, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York, NY, 10032, USA.
David RohDepartment of Neurology, Neurological Institute, Columbia University Medical Center, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York, NY, 10032, USA.
Soojin ParkDepartment of Neurology, Neurological Institute, Columbia University Medical Center, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York, NY, 10032, USA.
Jan ClaassenDepartment of Neurology, Neurological Institute, Columbia University Medical Center, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York, NY, 10032, USA. jc1439@columbia.edu.ORCID 0000-0002-5893-8531
Columbia University Irving Medical Center · USCentre National de la Recherche Scientifique · FRUniversity of Miami · US

Funding

Miami Clinical and Translational Science InstituteUL1TR002736 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN, KOBETZ, ERIN N · 2018 to 2022
$23.2M
RECONFIG - REcovery of CONsciousness Following Intracerebral hemorrhaGeR01NS106014 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLAASSEN, JAN · 2019 to 2023
$3.6M
Multiparametric Prediction of Vasospasm after Subarachnoid HemorrhageK01ES026833 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PARK, SOOJIN · 2015 to 2019
$1.1M
BAsIC - Brain-computer-interface practical Application in the Intensive Care unit: a pilot studyR03NS112760 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLAASSEN, JAN · 2019 to 2020
$162k
NCATS NIH HHS UL1 TR002736NIEHS NIH HHS K01 ES026833NINDS NIH HHS R01 NS106014NINDS NIH HHS R03 NS112760
6 · The paper itself

Abstract

backgroundElectroencephalography (EEG) findings following cardiovascular collapse in death are uncertain. We aimed to characterize EEG changes immediately preceding and following cardiac death.

methodsWe retrospectively analyzed EEGs of patients who died from cardiac arrest while undergoing standard EEG monitoring in an intensive care unit. Patients with brain death preceding cardiac death were excluded. Three events during fatal cardiovascular failure were investigated: (1) last recorded QRS complex on electrocardiogram (QRS

resultsAmong 19 patients who died while undergoing EEG monitoring, seven (37%) had a comfort-measures-only status and 18 (95%) had a do-not-resuscitate status in place at the time of death. EEG

conclusionsRarely may patients have transient electrocerebral activity following the last recorded QRS (less than 5 min) and estimated cessation of cerebral blood flow. These results may have implications for discussions around cardiopulmonary resuscitation and organ donation.

Indexed as

Cardiopulmonary ResuscitationHeart ArrestDeathElectroencephalographyHumansRetrospective StudiesBrain hypoxiaCardiac arrestConsciousnessDeathEncephalographyHypotension

Identifiers

PMID34184175
PMCPMC10008517
OpenAlexW3174578457

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.